Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 176-240, His)

(Synonyms: neuregulin 1) Copy Product Info

Synonyms: neuregulin 1

Catalog No. TMPY-04237 Copy Product Info

Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 176-240, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 9.7 kDa.

Pack Size	Price	USA Stock	Global Stock
5 µg	$39	7-10 days	7-10 days
10 µg	$59	7-10 days	7-10 days
20 µg	$94	7-10 days	7-10 days
50 µg	$183	7-10 days	7-10 days
100 µg	$353	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Information

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 176-240, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 9.7 kDa.
Species	Canine
Expression System	HEK293 Cells
Tag	N-His
Construction	A DNA sequence encoding the canine NRG1 (Ser176-Lys240) was expressed with a polyhistidine tag at the N-terminus. Predicted N terminal: His
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	neuregulin 1
Research Background	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

Chemical Properties

Molecular Weight

9.7 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Related Tags: Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 176-240, His) chemical structure | Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 176-240, His) molecular weight