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Bemnifosbuvir hemisulfate

Name: Bemnifosbuvir hemisulfate
Brand: TargetMol
SKU: T9331
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9331Cas No. 2241337-84-6

Alias AT-527

Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.

Bemnifosbuvir hemisulfate

🥰Excellent

Purity: 99.98%

Catalog No. T9331Alias AT-527Cas No. 2241337-84-6

Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	In Stock	In Stock
5 mg	$118	In Stock	In Stock
10 mg	$193	In Stock	In Stock
25 mg	$341	In Stock	In Stock
50 mg	$493	In Stock	In Stock
100 mg	$738	In Stock	In Stock
200 mg	$993	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.
Targets&IC50	HCV:5-28nM, SARS-CoV-2:0.47μM(EC90)
In vitro	The potent in vitro activity of AT-511, the free base of bemnifosbuvir hemisulfate, against several coronaviruses, including SARS-CoV-2. In normal human airway epithelial cells, the concentration of AT-511 required to inhibit replication of SARS-CoV-2 by 90% (EC90) was 0.47?μM, very similar to its EC90 against human coronavirus (HCoV)-229E, HCoV-OC43, and SARS-CoV in Huh-7 cells[1].
In vivo	When given orally to rats and monkeys, bemnifosbuvir hemisulfate preferentially delivered high levels of AT-9010 in the liver in vivo.These favorable preclinical attributes support bemnifosbuvir hemisulfate may increase SVR rates[2].
Synonyms	AT-527

Chemical Properties

Molecular Weight	1261.15
Formula	C₄₈H₆₈F₂N₁₄O₁₈P₂S
Cas No.	2241337-84-6
Smiles	C[C@@H](C(OC(C)C)=O)N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@H](N3C=NC4=C(NC)N=C(N)N=C34)[C@](C)(F)[C@@H]2O)=O.C[C@@H](C(OC(C)C)=O)N[P@@](OC5=CC=CC=C5)(OC[C@H]6O[C@@H](N7C=NC8=C(NC)N=C(N)N=C78)[C@](C)(F)[C@@H]6O)=O.O=S(O)(O)=O
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 170 mg/mL (269.60 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (3.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7929 mL	3.9646 mL	7.9293 mL	39.6464 mL
5 mM	0.1586 mL	0.7929 mL	1.5859 mL	7.9293 mL
10 mM	0.0793 mL	0.3965 mL	0.7929 mL	3.9646 mL
20 mM	0.0396 mL	0.1982 mL	0.3965 mL	1.9823 mL
50 mM	0.0159 mL	0.0793 mL	0.1586 mL	0.7929 mL
100 mM	0.0079 mL	0.0396 mL	0.0793 mL	0.3965 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc