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BAY-678

Name: BAY-678
Brand: TargetMol
SKU: T10473
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10473Cas No. 675103-36-3

BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).

BAY-678

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Purity: 97.89%

Catalog No. T10473Cas No. 675103-36-3

BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).

Pack Size	Price	Availability
5 mg	$33	In Stock
10 mg	$58	In Stock
25 mg	$128	In Stock
50 mg	$193	In Stock
100 mg	$293	In Stock
200 mg	$416	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:97.89%

ee:100%

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COA FNMR HNMR LCMS CSFC

Product Introduction

Bioactivity

Description	BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).
Targets&IC50	MNE:700 nM(Ki), HNE:20 nM
In vitro	BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium.[2] The Ki value of BAY-678 for MNE is 700 nM. BAY-678 is the 4th generation inhibitor of HNE.[1]
In vivo	BAY-678 reveals significant efficacy in preclinical models of ALI and lung emphysema. Additionally, BAY-678 has shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.[2]

Chemical Properties

Molecular Weight	400.35
Formula	C₂₀H₁₅F₃N₄O₂
Cas No.	675103-36-3
Smiles	CC(=O)C1=C(C)N(C(=O)N[C@@H]1c1ccc(nc1)C#N)c1cccc(c1)C(F)(F)F
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (224.8 mM), Sonication is recommended.

Ethanol: 4.3 mg/mL (10.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4978 mL	12.4891 mL	24.9781 mL	124.8907 mL
5 mM	0.4996 mL	2.4978 mL	4.9956 mL	24.9781 mL
10 mM	0.2498 mL	1.2489 mL	2.4978 mL	12.4891 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1249 mL	0.6245 mL	1.2489 mL	6.2445 mL
50 mM	0.0500 mL	0.2498 mL	0.4996 mL	2.4978 mL
100 mM	0.0250 mL	0.1249 mL	0.2498 mL	1.2489 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc