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CXCL4 Protein, Human, Recombinant (His)
(Synonyms: SCYB4, Platelet Factor 4, PF-4, PF4, Oncostatin-A, Iroplact, Harvey rat sarcoma viral oncogene homolog, CXCL4, C-X-C Motif Chemokine 4) Copy Product InfoSynonyms: SCYB4, Platelet Factor 4, PF-4, PF4, Oncostatin-A, Iroplact, Harvey rat sarcoma viral oncogene homolog, CXCL4, C-X-C Motif Chemokine 4
Catalog No. TMPJ-00012 Copy Product Info
Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $80 | - | In Stock | |
| 10 μg | $129 | - | In Stock | |
| 20 μg | $198 | - | In Stock | |
| 50 μg | $390 | - | In Stock | |
| 100 μg | $626 | - | In Stock | |
| 200 μg | $987 | 7-10 days | 7-10 days | |
| 500 μg | $1,900 | 7-10 days | 7-10 days | |
| 1 mg | $2,730 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:Greater than 95% as determined by reducing SDS-PAGE.
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes. |
| In vitro | Testing in progress |
| In vivo | Testing in progress |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | P02776 |
| Amino Acid | Glu32-Ser101 |
| Construction | Glu32-Ser101 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, 5% Trehalose, 5% Mannitol, 1 mM EDTA, 0.02% Tween 80, pH6.0. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | SCYB4, Platelet Factor 4, PF-4, PF4, Oncostatin-A, Iroplact, Harvey rat sarcoma viral oncogene homolog, CXCL4, C-X-C Motif Chemokine 4 |
| Research Background |
| Molecular Weight | 10—14 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: CXCL4 Protein, Human, Recombinant (His) chemical structure | CXCL4 Protein, Human, Recombinant (His) in vivo | CXCL4 Protein, Human, Recombinant (His) in vitro | CXCL4 Protein, Human, Recombinant (His) molecular weight
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