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P11

Name: P11
Brand: TargetMol
SKU: T24586
Rating: 4.5 (1 reviews)

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Catalog No. T24586Cas No. 942285-55-4

Alias PAFAH-1-b-2, PAFAH1b2, PAFAH 1 b 2, 3-IN-P11, 3INP11, 3 IN P11

P11 is a selective platelet-activating factor acetylhydrolase (PAFAH1b2 and PAFAH1b3) inhibitor, blocking PAFAH1b2/3-mediated hydrolysis of PAF to lysophosphatidic acid, used to study PAFAH1b2/3 cellular functions.

P11

😃Good

Catalog No. T24586Alias PAFAH-1-b-2, PAFAH1b2, PAFAH 1 b 2, 3-IN-P11, 3INP11, 3 IN P11Cas No. 942285-55-4

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$113	35 days	35 days
1 mg	$198	35 days	35 days
5 mg	$833	35 days	35 days
10 mg	$1,430	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	P11 is a selective platelet-activating factor acetylhydrolase (PAFAH1b2 and PAFAH1b3) inhibitor, blocking PAFAH1b2/3-mediated hydrolysis of PAF to lysophosphatidic acid, used to study PAFAH1b2/3 cellular functions.
Targets&IC50	PAFAH1b2:0.8 μM
In vitro	P11 showed particularly good efficacy against PAFAH1b2 with an IC50 value of 0.8 μM; P11 blocks the hydrolysis of PAFAH1b2 and Pafah1B3-mediated substrate PAF to hemolytic PAF with IC50 values of 36 and 880 nM, respectively. [1]
Synonyms	PAFAH-1-b-2, PAFAH1b2, PAFAH 1 b 2, 3-IN-P11, 3INP11, 3 IN P11

Chemical Properties

Molecular Weight	503.65
Formula	C₃₀H₃₃NO₄S
Cas No.	942285-55-4
Smiles	S(=O)(=O)(N1[C@H](C(C(O)=O)=CC[C@H]1C2=CC=C(C)C=C2)C3=CC=C(C(C)(C)C)C=C3)C4=CC=C(C)C=C4
Relative Density.	1.210 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (79.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9855 mL	9.9275 mL	19.8551 mL	99.2753 mL
5 mM	0.3971 mL	1.9855 mL	3.9710 mL	19.8551 mL
10 mM	0.1986 mL	0.9928 mL	1.9855 mL	9.9275 mL
20 mM	0.0993 mL	0.4964 mL	0.9928 mL	4.9638 mL
50 mM	0.0397 mL	0.1986 mL	0.3971 mL	1.9855 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PAFAH-1b2

P11

P11

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