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FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)

Catalog No. TMPY-06035
Synonyms: KAL2, OGD, N-SAM, CEK, FLT2, HH2, FLG, CD331, BFGFR, HBGFR, FLT-2, FGFBR, FGFR1 α (IIIc), HRTFDS, fibroblast growth factor receptor 1, FGFR-1, bFGF-R-1

FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7.

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FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)
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200 μg 5 days $ 904.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number P11362-7
Synonyms KAL2, OGD, N-SAM, CEK, FLT2, HH2, FLG, CD331, BFGFR, HBGFR, FLT-2, FGFBR, FGFR1 α (IIIc), HRTFDS, fibroblast growth factor receptor 1, FGFR-1, bFGF-R-1
Construction The Human FGFR1 alpha (IIIb) (NP_056934.2) (Met1-Lys310 and Ala359-Glu374 linked by FGFR1 IIIb Ig domain (AAB19502.1) (His1-Pro47)) was expressed with the Fc region of Human IgG1 at the C-terminus.
Protein Purity > 90 % as determined by SDS-PAGE.
Molecular Weight 65.7 kDa (predicted)
Endotoxin < 1.0 EU/μg protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ,idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

References and Literature

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Keywords

FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) KAL2 OGD N-SAM KAL 2 CEK FLT2 HH2 FGFR 1 FLG CD331 FGFR1 BFGFR HBGFR FLT-2 FGFBR KAL-2 FLT 2 FGFR1 α (IIIc) HRTFDS HH 2 CD-331 fibroblast growth factor receptor 1 CD 331 FGFR-1 HH-2 bFGF-R-1 recombinant recombinant-proteins proteins protein

 

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