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BI 689648

Name: BI 689648
Brand: TargetMol
SKU: T14664
Rating: 4.5 (1 reviews)

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Catalog No. T14664Cas No. 1633009-87-6

BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively).

BI 689648

😃Good

Catalog No. T14664Cas No. 1633009-87-6

BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$985	6-8 weeks	6-8 weeks
50 mg	$1,280	6-8 weeks	6-8 weeks
100 mg	$1,940	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$272	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively).
Targets&IC50	CYP11B2:2.1 nM, CYP11B1:310 nM
In vitro	In comparison with FADs and LCI699, BI 689648 exhibits remarkable selectivity in vitro, demonstrating an IC50 value of 2.1 nM for CYP11B2 and a selectivity factor of 149 over CYP11B1. Meanwhile, FAD286 presents a comparable IC50 value for CYP11B2 at 2.5 nM, but its higher efficacy against CYP11B1 (94 nM) yields a relatively lower selectivity factor of 38, which is about fourfold lesser than that of BI 689648[1].
In vivo	After oral administration in cyno monkeys, BI 689648 (5 mg/kg) achieves a peak plasma concentration of ~500 nM. BI 689648 minimally impacts 11-DC, but only at very high plasma concentrations (~10 μM)[1]. For BI 689648 (aldosterone EC50 = 2 nM), significant changes in 11-DOC are observed at plasma concentrations >2000 nM or >1000-fold its aldosterone EC50, whereas FAD286 exhibits a window of ~100-fold.

Chemical Properties

Molecular Weight	298.34
Formula	C₁₆H₁₈N₄O₂
Cas No.	1633009-87-6
Smiles	COCc1cncc(c1)-c1cnc2N(CCCc2c1)C(N)=O
Relative Density.	1.260 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (100.56 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.7 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3519 mL	16.7594 mL	33.5188 mL	167.5940 mL
5 mM	0.6704 mL	3.3519 mL	6.7038 mL	33.5188 mL
10 mM	0.3352 mL	1.6759 mL	3.3519 mL	16.7594 mL
20 mM	0.1676 mL	0.8380 mL	1.6759 mL	8.3797 mL
50 mM	0.0670 mL	0.3352 mL	0.6704 mL	3.3519 mL
100 mM	0.0335 mL	0.1676 mL	0.3352 mL	1.6759 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc