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UC-1V150 is a distinct TLR7 agonist, which activates cellular immune responses and exhibits anti-tumor effects. It also serves as a precursor for the synthesis of ISAC molecules, known as immune-stimulating antibody conjugates [1] [2].

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
| Description | UC-1V150 is a distinct TLR7 agonist, which activates cellular immune responses and exhibits anti-tumor effects. It also serves as a precursor for the synthesis of ISAC molecules, known as immune-stimulating antibody conjugates [1] [2]. |
| In vitro | UC-1V150, at concentrations ranging from 0.01 to 10 μM over a 24-hour period, effectively promotes the secretion of IL-6 and IL-2 cytokines in bone-marrow-derived macrophages [1]. Additionally, when administered at 1 μg/mL for 48 hours, it enhances the expression of FcγRIIA and FcγRIII and induces a roughly 1.5-fold enhancement in the phagocytosis index of target cells in human monocyte-derived macrophages (hMDM) [2]. |
| In vivo | UC-1V150, administered via a single intravenous injection at concentrations ranging from 0.38-38 nM for 2 hours, effectively triggers the release of serum cytokines in female C57BL/6 mice aged 5-6 weeks. This administration resulted in serum interleukin-6 (IL-6) levels reaching approximately 0.1 ng/mL and interleukin-2 (IL-2) levels reaching approximately 1.5 ng/mL at the 38 nM concentration. |
| Molecular Weight | 343.34 |
| Formula | C16H17N5O4 |
| Cas No. | 927822-45-5 |
| Smiles | C(N1C=2C(NC1=O)=C(N)N=C(OCCOC)N2)C3=CC=C(C=O)C=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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