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Anti-Phospho-FGFR1 (Tyr766) Polyclonal Antibody 2
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Catalog No. TMAC-01463
Anti-Phospho-FGFR1 (Tyr766) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FGFR1 (Tyr766). Anti-Phospho-FGFR1 (Tyr766) Polyclonal Antibody can be used in WB.
Anti-Phospho-FGFR1 (Tyr766) Polyclonal Antibody 2
Anti-Phospho-FGFR1 (Tyr766) Polyclonal Antibody 2
😃Good
Catalog No. TMAC-01463
Anti-Phospho-FGFR1 (Tyr766) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FGFR1 (Tyr766). Anti-Phospho-FGFR1 (Tyr766) Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $218 | 7-10 days | |
| 100 μL | $317 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-Phospho-FGFR1 (Tyr766) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FGFR1 (Tyr766). Anti-Phospho-FGFR1 (Tyr766) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Rat |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 766 (Q-E-Y(p)-L-D) derived from FGFR1 |
| Antigen Species | Peptide sequence around phosphorylation site of tyrosine 766 (Q-E-Y(p)-L-D) derived from FGFR1 |
| Uniprot ID |
| Molecular Weight | Actual: 140 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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