Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-28583113, a TRPM2 antagonist with brain permeability, inhibits the phosphorylation of GSK3α and β subunits, thereby protecting cells from oxidative stress-induced cell death. Additionally, it suppresses cytokine release in response to pro-inflammatory stimuli in microglia [1].
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Description | JNJ-28583113, a TRPM2 antagonist with brain permeability, inhibits the phosphorylation of GSK3α and β subunits, thereby protecting cells from oxidative stress-induced cell death. Additionally, it suppresses cytokine release in response to pro-inflammatory stimuli in microglia [1]. |
Molecular Weight | 366.38 |
Formula | C19H21F3N2O2 |
CAS No. | 2765255-93-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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JNJ-28583113 2765255-93-2 inhibitor inhibit