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VRT-325
(Synonyms: VRT-534, VRT325, VRT 325, CFcor-325, CFcor325, CFcor 325, CF-106951) Copy Product Info
🥰Excellent
Synonyms: VRT-534, VRT325, VRT 325, CFcor-325, CFcor325, CFcor 325, CF-106951
Catalog No. T35074 Copy Product Info
Purity: 99.58%
🥰Excellent
VRT-325 is a CFTR modulator with the ability to promote ΔF508-CFTR folding and endoplasmic reticulum trafficking. VRT-325 restores chloride transport in bronchial epithelial cells from cystic fibrosis patients and accelerates healing of CF cell monolayers, used for experimental research in cystic fibrosis.
Cas No. 815592-21-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $350 | In Stock | In Stock | |
| 5 mg | $970 | In Stock | In Stock | |
| 10 mg | $1,200 | In Stock | In Stock | |
| 25 mg | $1,590 | In Stock | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.58%
Appearance:Solid
Color:White
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Product Introduction
VRT-325 AI Summary
VRT-325 exhibits corrector activity on the CFTR F508 deletion mutant expressed in various cell models, including human FRT cells, human CFBE41o cells, and mouse NIH/3T3 cells. In human FRT cells, it shows an Emax of 92.9% and an EC50 of 2200.0 nM after 25 minutes of incubation with forskolin, assessed by YFP-based fluorescence. In human CFBE41o cells, the compound demonstrates an EC50 of 2187.76 nM after preincubation for 24 hours followed by 30 minutes of stimulation with forskolin and genistein, evaluated using a fluorescence assay. In mouse NIH/3T3 cells, it has an EC50 of 3300.0 nM in a DiSBAC2 dye-based FRET assay, which includes preincubation for 16 hours before forskolin and genistein addition. Additionally, VRT-325 has a solubility of 1000.0 nM in a 50 mM ammonium acetate buffer at pH 7.4 after 24 hours and demonstrates a metabolic stability of 13.0%, as assessed by recombinant human CYP3A4-mediated drug degradation..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | VRT-325 is a CFTR modulator with the ability to promote ΔF508-CFTR folding and endoplasmic reticulum trafficking. VRT-325 restores chloride transport in bronchial epithelial cells from cystic fibrosis patients and accelerates healing of CF cell monolayers, used for experimental research in cystic fibrosis. |
| In vitro | Methods: BHK cells were treated with approximately 2 μM VRT-325, and CFTR protein maturation was assessed by Western blot. Results: VRT-325 significantly promoted Delta F508-CFTR maturation and membrane expression, with enhanced efficacy when combined with Corr-2b.[1] |
| Synonyms | VRT-534, VRT325, VRT 325, CFcor-325, CFcor325, CFcor 325, CF-106951 |
| Molecular Weight | 510.65 |
| Formula | C27H34N4O4S |
| Cas No. | 815592-21-3 |
| Smiles | O(C=1C2=C(N=C(C(C)N3CCN(S(=O)(=O)C4=CC=C(OC)C=C4)CC3)N1)C=CC=C2)C5CCCCC5 |
| Relative Density. | 1.268 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (88.12 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: VRT-325 chemical structure | VRT-325 in vitro | VRT-325 formula | VRT-325 molecular weight
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