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VRT-325

Name: VRT-325
Brand: TargetMol
SKU: T35074
Price: 350 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35074Cas No. 815592-21-3

Alias VRT-534, VRT325, VRT 325, CFcor-325, CFcor325, CFcor 325, CF-106951

VRT-325 can repair folding defects by promoting dimerization of the two NBDs or by promoting folding of the TMD.VRT-325 accelerates the healing rate of CF cell monolayers.

VRT-325

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Purity: 99.58%

Catalog No. T35074Alias VRT-534, VRT325, VRT 325, CFcor-325, CFcor325, CFcor 325, CF-106951Cas No. 815592-21-3

VRT-325 can repair folding defects by promoting dimerization of the two NBDs or by promoting folding of the TMD.VRT-325 accelerates the healing rate of CF cell monolayers.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$350	In Stock	In Stock
5 mg	$970	In Stock	In Stock
10 mg	$1,200	In Stock	In Stock
25 mg	$1,590	In Stock	In Stock
50 mg	$1,980	-	In Stock
100 mg	$2,500	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.58%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

VRT-325 AI Summary

VRT-325 exhibits corrector activity on the CFTR F508 deletion mutant expressed in various cell models, including human FRT cells, human CFBE41o cells, and mouse NIH/3T3 cells. In human FRT cells, it shows an Emax of 92.9% and an EC50 of 2200.0 nM after 25 minutes of incubation with forskolin, assessed by YFP-based fluorescence. In human CFBE41o cells, the compound demonstrates an EC50 of 2187.76 nM after preincubation for 24 hours followed by 30 minutes of stimulation with forskolin and genistein, evaluated using a fluorescence assay. In mouse NIH/3T3 cells, it has an EC50 of 3300.0 nM in a DiSBAC2 dye-based FRET assay, which includes preincubation for 16 hours before forskolin and genistein addition. Additionally, VRT-325 has a solubility of 1000.0 nM in a 50 mM ammonium acetate buffer at pH 7.4 after 24 hours and demonstrates a metabolic stability of 13.0%, as assessed by recombinant human CYP3A4-mediated drug degradation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	VRT-325 can repair folding defects by promoting dimerization of the two NBDs or by promoting folding of the TMD.VRT-325 accelerates the healing rate of CF cell monolayers.
Synonyms	VRT-534, VRT325, VRT 325, CFcor-325, CFcor325, CFcor 325, CF-106951

Chemical Properties

Molecular Weight	510.65
Formula	C₂₇H₃₄N₄O₄S
Cas No.	815592-21-3
Smiles	O(C=1C2=C(N=C(C(C)N3CCN(S(=O)(=O)C4=CC=C(OC)C=C4)CC3)N1)C=CC=C2)C5CCCCC5
Relative Density.	1.268 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (88.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9583 mL	9.7914 mL	19.5829 mL	97.9144 mL
5 mM	0.3917 mL	1.9583 mL	3.9166 mL	19.5829 mL
10 mM	0.1958 mL	0.9791 mL	1.9583 mL	9.7914 mL
20 mM	0.0979 mL	0.4896 mL	0.9791 mL	4.8957 mL
50 mM	0.0392 mL	0.1958 mL	0.3917 mL	1.9583 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc