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STAT3-IN-13

Catalog No. T62491 CAS 2248552-86-3

STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705, which induces apoptosis and inhibits tumor cell growth and metastasis.STAT3-IN-13 can be used to study breast cancer and liver cancer. The study of breast cancer and hepatocellular carcinoma.

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STAT3-IN-13, CAS 2248552-86-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 196.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 428.00
50 mg	In stock	$ 897.00
100 mg	In stock	$ 1,160.00

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Purity: 98.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705, which induces apoptosis and inhibits tumor cell growth and metastasis.STAT3-IN-13 can be used to study breast cancer and liver cancer. The study of breast cancer and hepatocellular carcinoma.
Targets&IC50	MG63 cell:0.55 μM, 143B:0.25 μM, HOS:0.11 μM, STAT3:0.96 μM (Kd)
In vitro	STAT3-IN-13 (compound 6f), over a period of 48 hours, demonstrates anti-proliferative activity with IC50 values of 0.25, 0.11, and 0.55 μM for 143B, HOS, and MG63 cells, respectively [1].In the concentration range of 0.001-100 μM, STAT3-IN-13 (compound 6f) binds to STAT3 and interacts with STAT3^586-685 in a concentration-dependent manner, with a KD of 0.96 μM [1].Over a period of 24 hours at concentrations ranging from 0 to 1.0 μM in 143B and HOS cells, STAT3-IN-13 (compound 6f) inhibits STAT3 Y705 phosphorylation and suppresses STAT3 in tumor cells [1].At concentrations ranging from 0 to 1.0 μM over 48 hours in 143B cells, STAT3-IN-13 (compound 6f) induces apoptosis in a dose-dependent manner [1].
In vivo	In vivo, STAT3-IN-13 (compound 6f), administered intraperitoneally at doses of 10-20 mg/kg twice daily for 4 weeks in nude mice, effectively blocks osteosarcoma growth and metastasis [1].

Molecular Weight	436.49
Formula	C21H20N6O3S
CAS No.	2248552-86-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (183.28 mM), Sonication is recommended.

References and Literature

1. Jin W, et al. Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis. J Med Chem. 2022 May 12;65(9):6710-6728.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library

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Keywords

STAT3-IN-13 2248552-86-3 JAK/STAT signaling Stem Cells STAT inhibitor inhibit

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