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L-Aspartic acid-13C

Name: L-Aspartic acid-13C
Brand: TargetMol
SKU: T40915
Rating: 4.5 (1 reviews)

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L-Aspartic acid-13C is 13C-labeled L-aspartic acid. L-aspartic acid serves as a precursor molecule for energy and nitrogen metabolism, participates in the tricarboxylic acid (TCA) cycle and the urea cycle, and influences neurotransmitter synthesis. L-aspartic acid is commonly used in research on inflammatory diseases and metabolism.

Cas No. 81201-97-0

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Batch Information

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Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description

In vitro

L-Aspartic acid has been shown to be a suitable prodrug for colon-specific drug delivery. [1]
Following pretreatment with 100 mM L-aspartic acid and 100 mM L-glutamic acid, the levels of L-[3H]Asp remaining in the brain at 5 minutes increased by 206% and 178%, respectively, whereas 100 mM D-Asp had no effect on the efflux of L- [3H]Asp. When co-administered with 100 mM L-aspartic acid and 100 mM L-Glu, the levels of L-[3H]Glu at 20 minutes increased by 145% and 156%, respectively, whereas D-Asp did not. The apparent efflux rate of L-aspartic acid across the blood-brain barrier (BBB) is seven times that of L-Glu.[2]

Chemical Properties

Molecular Weight	134.10
Formula	C₄H₇NO₄
Cas No.	81201-97-0
Smiles	[C@H](CC(O)=O)([13C](O)=O)N
Relative Density.	no data available
Sequence	Asp-¹³C
Sequence Short	D-¹³C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 16 mg/mL (119.31 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	7.4571 mL	37.2856 mL	74.5712 mL	372.8561 mL
5 mM	1.4914 mL	7.4571 mL	14.9142 mL	74.5712 mL
10 mM	0.7457 mL	3.7286 mL	7.4571 mL	37.2856 mL
20 mM	0.3729 mL	1.8643 mL	3.7286 mL	18.6428 mL
50 mM	0.1491 mL	0.7457 mL	1.4914 mL	7.4571 mL
100 mM	0.0746 mL	0.3729 mL	0.7457 mL	3.7286 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

L-Aspartic acid 13CLAspartic acid 13CL Aspartic acid 13C

Related Tags: L-Aspartic acid-13C chemical structure | L-Aspartic acid-13C in vitro | L-Aspartic acid-13C formula | L-Aspartic acid-13C molecular weight