keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MAIT-203, a cyclopentyalanin-derived peptidomimetic, effectively disrupts the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), without affecting APC-Sam68 or APC-striatin interactions. It binds to APC-ARM domains with a K i of 0.015 μM and a K d of 0.036 μM, and notably inhibits the migration and invasion of colorectal cancer cells.
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Description | MAIT-203, a cyclopentyalanin-derived peptidomimetic, effectively disrupts the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), without affecting APC-Sam68 or APC-striatin interactions. It binds to APC-ARM domains with a K i of 0.015 μM and a K d of 0.036 μM, and notably inhibits the migration and invasion of colorectal cancer cells. |
In vitro | MAIT-203 at concentrations of 10 μM and 25 μM significantly attenuates the interaction between Asef and APC in HEK293T cells, demonstrating a dose-dependent effect over a 24-hour period [1]. |
Molecular Weight | N/A |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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