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Anti-Phospho-PLK1 (Ser137) Polyclonal Antibody

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Catalog No. TMAC-03384

Anti-Phospho-PLK1 (Ser137) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PLK1 (Ser137). Anti-Phospho-PLK1 (Ser137) Polyclonal Antibody can be used in WB.

Anti-Phospho-PLK1 (Ser137) Polyclonal Antibody

Anti-Phospho-PLK1 (Ser137) Polyclonal Antibody

😃Good
Catalog No. TMAC-03384
Anti-Phospho-PLK1 (Ser137) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PLK1 (Ser137). Anti-Phospho-PLK1 (Ser137) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2177-10 days
100 μL$3187-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-PLK1 (Ser137) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PLK1 (Ser137). Anti-Phospho-PLK1 (Ser137) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-3000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundSerine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of serine 137 (R-R-S(p)-L-L) derived from Human PLK1
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 68 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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