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PSB-06126 is a selective NTPDase3 (nucleotide triphosphate diphosphate hydrolase 3) inhibitor with a Ki of 1.5 μM for rat NTPDase3 and an IC50 of 7.76 μM for human NTPDase3 (Ki = 4.39 μM). It is suitable for investigating cancer and immune-related diseases.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $35 | In Stock | |
5 mg | $81 | In Stock | |
10 mg | $129 | In Stock | |
25 mg | $218 | In Stock | |
50 mg | $325 | In Stock | |
100 mg | $483 | In Stock | |
1 mL x 10 mM (in DMSO) | $83 | In Stock |
Description | PSB-06126 is a selective NTPDase3 (nucleotide triphosphate diphosphate hydrolase 3) inhibitor with a Ki of 1.5 μM for rat NTPDase3 and an IC50 of 7.76 μM for human NTPDase3 (Ki = 4.39 μM). It is suitable for investigating cancer and immune-related diseases. |
In vitro | In mesenchymal stem cells (MSCs), PSB-06126 (3 μM) can block the overexpression of NTPDase3. PSB-06126 increases extracellular ATP levels by activating P2X7 and P2Y6 receptors, ultimately promoting osteogenic differentiation and mineralization of MSCs.[3] |
Molecular Weight | 466.44 |
Formula | C24H15N2NaO5S |
Cas No. | 1052089-16-3 |
Smiles | O=C1C2=C(C(C3=C(NC4=CC=CC5=C4C=CC=C5)C=C(S(=O)([O-])=O)C(N)=C13)=O)C=CC=C2.[Na+] |
Relative Density. | no data available |
Color | Purple |
Appearance | Solid |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Solubility Information | Ethanol: <23.32 mg/mL, Sonication is recommended. DMSO: <46.64 mg/mL, Sonication is recommended. |
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