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PSB-06126

🥰Excellent
Catalog No. T23193Cas No. 1052089-16-3
Alias PSB06126

PSB-06126 is a selective NTPDase3 (nucleotide triphosphate diphosphate hydrolase 3) inhibitor with a Ki of 1.5 μM for rat NTPDase3 and an IC50 of 7.76 μM for human NTPDase3 (Ki = 4.39 μM). It is suitable for investigating cancer and immune-related diseases.

PSB-06126

PSB-06126

🥰Excellent
Purity: 99.59%
Catalog No. T23193Alias PSB06126Cas No. 1052089-16-3
PSB-06126 is a selective NTPDase3 (nucleotide triphosphate diphosphate hydrolase 3) inhibitor with a Ki of 1.5 μM for rat NTPDase3 and an IC50 of 7.76 μM for human NTPDase3 (Ki = 4.39 μM). It is suitable for investigating cancer and immune-related diseases.
Pack SizePriceAvailabilityQuantity
1 mg$35In Stock
5 mg$81In Stock
10 mg$129In Stock
25 mg$218In Stock
50 mg$325In Stock
100 mg$483In Stock
1 mL x 10 mM (in DMSO)$83In Stock
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Purity:99.59%
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Product Introduction

Bioactivity
Description
PSB-06126 is a selective NTPDase3 (nucleotide triphosphate diphosphate hydrolase 3) inhibitor with a Ki of 1.5 μM for rat NTPDase3 and an IC50 of 7.76 μM for human NTPDase3 (Ki = 4.39 μM). It is suitable for investigating cancer and immune-related diseases.
Targets&IC50
NTPDase1 (rat):0.33 μM (Ki), NTPDase3 (rat):2.22 μM (Ki), NTPDase2 (rat):19.1 μM (Ki), NTPDase3 (human):4.39 μM (Ki)
In vitro
In mesenchymal stem cells (MSCs), PSB-06126 (3 μM) can block the overexpression of NTPDase3. PSB-06126 increases extracellular ATP levels by activating P2X7 and P2Y6 receptors, ultimately promoting osteogenic differentiation and mineralization of MSCs.[3]
SynonymsPSB06126
Chemical Properties
Molecular Weight466.44
FormulaC24H15N2NaO5S
Cas No.1052089-16-3
SmilesO=C1C2=C(C(C3=C(NC4=CC=CC5=C4C=CC=C5)C=C(S(=O)([O-])=O)C(N)=C13)=O)C=CC=C2.[Na+]
Relative Density.no data available
ColorPurple
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: <23.32 mg/mL, Sonication is recommended.
DMSO: 100 mg/mL (214.39 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1439 mL10.7195 mL21.4390 mL107.1949 mL
5 mM0.4288 mL2.1439 mL4.2878 mL21.4390 mL
10 mM0.2144 mL1.0719 mL2.1439 mL10.7195 mL
20 mM0.1072 mL0.5360 mL1.0719 mL5.3597 mL
50 mM0.0429 mL0.2144 mL0.4288 mL2.1439 mL
100 mM0.0214 mL0.1072 mL0.2144 mL1.0719 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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