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PSB-06126

Name: PSB-06126
Brand: TargetMol
SKU: T23193
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T23193Cas No. 1052089-16-3

Alias PSB06126

PSB-06126 is a selective NTPDase3 (nucleotide triphosphate diphosphate hydrolase 3) inhibitor with a Ki of 1.5 μM for rat NTPDase3 and an IC50 of 7.76 μM for human NTPDase3 (Ki = 4.39 μM). It is suitable for investigating cancer and immune-related diseases.

PSB-06126

🥰Excellent

Purity: 99.59%

Catalog No. T23193Alias PSB06126Cas No. 1052089-16-3

Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$81	In Stock
10 mg	$129	In Stock
25 mg	$218	In Stock
50 mg	$325	In Stock
100 mg	$483	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock

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Purity:99.59%

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Product Introduction

Bioactivity

Description	PSB-06126 is a selective NTPDase3 (nucleotide triphosphate diphosphate hydrolase 3) inhibitor with a Ki of 1.5 μM for rat NTPDase3 and an IC50 of 7.76 μM for human NTPDase3 (Ki = 4.39 μM). It is suitable for investigating cancer and immune-related diseases.
Targets&IC50	NTPDase1 (rat):0.33 μM (Ki), NTPDase3 (rat):2.22 μM (Ki), NTPDase2 (rat):19.1 μM (Ki), NTPDase3 (human):4.39 μM (Ki)
In vitro	In mesenchymal stem cells (MSCs), PSB-06126 (3 μM) can block the overexpression of NTPDase3. PSB-06126 increases extracellular ATP levels by activating P2X7 and P2Y6 receptors, ultimately promoting osteogenic differentiation and mineralization of MSCs.[3]
Synonyms	PSB06126

Chemical Properties

Molecular Weight	466.44
Formula	C₂₄H₁₅N₂NaO₅S
Cas No.	1052089-16-3
Smiles	O=C1C2=C(C(C3=C(NC4=CC=CC5=C4C=CC=C5)C=C(S(=O)([O-])=O)C(N)=C13)=O)C=CC=C2.[Na+]
Relative Density.	no data available
Color	Purple
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: <23.32 mg/mL, Sonication is recommended.

DMSO: 100 mg/mL (214.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1439 mL	10.7195 mL	21.4390 mL	107.1949 mL
5 mM	0.4288 mL	2.1439 mL	4.2878 mL	21.4390 mL
10 mM	0.2144 mL	1.0719 mL	2.1439 mL	10.7195 mL
20 mM	0.1072 mL	0.5360 mL	1.0719 mL	5.3597 mL
50 mM	0.0429 mL	0.2144 mL	0.4288 mL	2.1439 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	1.0719 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc