Shopping Cart

Your shopping cart is currently empty

PSB-06126

Name: PSB-06126
Brand: TargetMol
SKU: T23193
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T23193Cas No. 1052089-16-3

Alias PSB06126

PSB-06126 is a selective NTPDase3 (nucleotide triphosphate diphosphate hydrolase 3) inhibitor with a Ki of 1.5 μM for rat NTPDase3 and an IC50 of 7.76 μM for human NTPDase3 (Ki = 4.39 μM). It is suitable for investigating cancer and immune-related diseases.

PSB-06126

Copy Product Info

😃Good

Purity: 99.59%

Catalog No. T23193Alias PSB06126Cas No. 1052089-16-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$81	-	In Stock
10 mg	$129	-	In Stock
25 mg	$218	-	In Stock
50 mg	$325	-	In Stock
100 mg	$483	-	In Stock
1 mL x 10 mM (in DMSO)	$83	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.59%

Appearance:Solid

Color:Purple

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PSB-06126 is a selective NTPDase3 (nucleotide triphosphate diphosphate hydrolase 3) inhibitor with a Ki of 1.5 μM for rat NTPDase3 and an IC50 of 7.76 μM for human NTPDase3 (Ki = 4.39 μM). It is suitable for investigating cancer and immune-related diseases.
Targets&IC50	NTPDase1 (rat):0.33 μM (Ki), NTPDase3 (human):4.39 μM (Ki), NTPDase3 (rat):2.22 μM (Ki), NTPDase2 (rat):19.1 μM (Ki)
In vitro	In mesenchymal stem cells (MSCs), PSB-06126 (3 μM) can block the overexpression of NTPDase3. PSB-06126 increases extracellular ATP levels by activating P2X7 and P2Y6 receptors, ultimately promoting osteogenic differentiation and mineralization of MSCs.[3]
Synonyms	PSB06126

Chemical Properties

Molecular Weight	466.44
Formula	C₂₄H₁₅N₂NaO₅S
Cas No.	1052089-16-3
Smiles	O=C1C2=C(C(C3=C(NC4=CC=CC5=C4C=CC=C5)C=C(S(=O)([O-])=O)C(N)=C13)=O)C=CC=C2.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: <23.32 mg/mL, Sonication is recommended.

DMSO: 100 mg/mL (214.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1439 mL	10.7195 mL	21.4390 mL	107.1949 mL
5 mM	0.4288 mL	2.1439 mL	4.2878 mL	21.4390 mL
10 mM	0.2144 mL	1.0719 mL	2.1439 mL	10.7195 mL
20 mM	0.1072 mL	0.5360 mL	1.0719 mL	5.3597 mL
50 mM	0.0429 mL	0.2144 mL	0.4288 mL	2.1439 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	1.0719 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc