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Bc1-w Protein, Human, Recombinant (His)
(Synonyms: KIAA0271, BCLW, Bcl-2-Like Protein 2, Bcl2-L-2, BCL2L2, Apoptosis Regulator Bcl-W) Copy Product InfoSynonyms: KIAA0271, BCLW, Bcl-2-Like Protein 2, Bcl2-L-2, BCL2L2, Apoptosis Regulator Bcl-W
Catalog No. TMPJ-00584 Copy Product Info
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $61 | 35 days | 35 days | |
| 10 μg | $97 | 35 days | 35 days | |
| 20 μg | $158 | 35 days | 35 days | |
| 50 μg | $310 | 35 days | 35 days | |
| 100 μg | $532 | 35 days | 35 days | |
| 200 μg | $919 | 35 days | 35 days | |
| 500 μg | $1,900 | 35 days | 35 days | |
| 1 mg | $2,730 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. |
| Species | Human |
| Expression System | E. coli |
| Tag | C-6xHis |
| Accession Number | AAI13523.1 |
| Amino Acid | Ala2-Thr172 |
| Construction | Ala2-Thr172 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Supplied as a 0.2 μm filtered solution of 25 mM HEPES, 100 mM KCl, 20% Glycerol, pH 7.5. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Proteins are shipped with blue ice. |
| Synonyms | KIAA0271, BCLW, Bcl-2-Like Protein 2, Bcl2-L-2, BCL2L2, Apoptosis Regulator Bcl-W |
| Research Background |
| Molecular Weight | 18 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Bc1-w Protein, Human, Recombinant (His) chemical structure | Bc1-w Protein, Human, Recombinant (His) molecular weight
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