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rac-CCT-250863 HCl

Name: rac-CCT-250863 HCl
Brand: TargetMol
SKU: T28498L
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T28498L

Alias rac-CCT-250863 HCl(1364269-06-6 Free base)

rac-CCT-250863 HCl is a selective and reversible inhibitor of NEK 2. rac-CCT-250863 HCl induces cell cycle arrest and has good anti-proliferative activity against cancer cells. rac-CCT-250863 HCl can be used in combination with Pomalidomide to induce apoptosis and can be used in combined anti-cancer studies.

rac-CCT-250863 HCl

😃Good

Purity: 98.21%

Catalog No. T28498LAlias rac-CCT-250863 HCl(1364269-06-6 Free base)

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	Inquiry	Inquiry
5 mg	$440	Inquiry	Inquiry
50 mg	$1,390	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$552	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.21%

Appearance:Oil

Color:Orange

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	rac-CCT-250863 HCl is a selective and reversible inhibitor of NEK 2. rac-CCT-250863 HCl induces cell cycle arrest and has good anti-proliferative activity against cancer cells. rac-CCT-250863 HCl can be used in combination with Pomalidomide to induce apoptosis and can be used in combined anti-cancer studies.
Targets&IC50	H929 multiple myeloma cells:8.0 μΜ, K12PE:8.7 μΜ, NEK2:0.073 µM, AMOL:7.1 μΜ
Synonyms	rac-CCT-250863 HCl(1364269-06-6 Free base)

Chemical Properties

Molecular Weight	527
Formula	C₂₄H₂₆ClF₃N₄O₂S
Smiles	NC1=C(C=C(C=N1)C2=CC(CN(C)C)=CS2)C3=CC(OC(/C=C\C(F)(F)F)C)=C(C(N)=O)C=C3.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (42.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8975 mL	9.4877 mL	18.9753 mL	94.8767 mL
5 mM	0.3795 mL	1.8975 mL	3.7951 mL	18.9753 mL
10 mM	0.1898 mL	0.9488 mL	1.8975 mL	9.4877 mL
20 mM	0.0949 mL	0.4744 mL	0.9488 mL	4.7438 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc