A2AR/A2BR antagonist 1

Name: A2AR/A2BR antagonist 1
Brand: TargetMol
SKU: T209474
Rating: 4.5 (1 reviews)

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Catalog No. T209474

A2AR/A2BR antagonist 1 (compound 7ai) acts as a dual antagonist to A2AR and A2BR with IC50 values of 11.2 nM and 6.4 nM, respectively. Additionally, A2AR/A2BR antagonist 1 enhances T cell-mediated cancer cell death.

A2AR/A2BR antagonist 1

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Catalog No. T209474

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Product Introduction

Bioactivity

Description	A2AR/A2BR antagonist 1 (compound 7ai) acts as a dual antagonist to A2AR and A2BR with IC50 values of 11.2 nM and 6.4 nM, respectively. Additionally, A2AR/A2BR antagonist 1 enhances T cell-mediated cancer cell death.
Targets&IC50	A2BR:6.4 nM, A2AR:11.2 nM
In vitro	The compound 2A R/A 2B R antagonist 1 (compound 7ai) at concentrations of 0.1, 1, and 10 μM over 0-48 hours can reverse NECA-induced immunosuppression, thereby enhancing OT-I CTL cell activation and cytotoxicity, leading to antitumor activity.

Chemical Properties

Formula

C₂₄H₁₇N₉

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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