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AM103

Name: AM103
Brand: TargetMol
SKU: T10314
Price: 146 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10314Cas No. 1147872-22-7

Alias AM 103

AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).

AM103

🥰Excellent

Purity: 99.75%

Catalog No. T10314Alias AM 103Cas No. 1147872-22-7

AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$146	In Stock	In Stock
5 mg	$363	In Stock	In Stock
10 mg	$546	In Stock	In Stock
25 mg	$983	In Stock	In Stock
50 mg	$1,370	In Stock	In Stock
100 mg	$1,880	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.75%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).
Targets&IC50	FLAP:4.2 nM
In vitro	AM103 is against the 5 most common CYP isoforms with IC50s >30 μM for CYP2D6 and >50 μM for CYP3A4, CYP2C9, CYP2C19, and CYP1A2[1]. AM103 shows IC50s of 350, 113, and 117 nM against human, rat, and mouse whole-blood ionophore-stimulated LTB4 production, respectively[2].
In vivo	AM103 has high bioavailability of 64%, low clearance of 2.9 mL/min/kg, low volume of distribution of 0.41 L/kg, and a long i.v. half-life of 5.2 h in dogs. AM103 (10 mg/kg) inhibits the increase in CysLTs and EPO by approximately 60% and reduces the level of IL-5[1]. In a model of chronic lung inflammation using ovalbumin-primed and challenged BALB/c mice, AM103 reduces eosinophil peroxidase, CysLTs, and IL-5 in the bronchoalveolar lavage fluid. AM103 increases survival time in mice exposed to a lethal intravenous injection of platelet-activating factor. In the rat lung challenged in vivo with calcium ionophore, AM103 inhibits LTB4 and cysteinyl leukotriene production with ED50 values of 0.8 and 1 mg/kg, respectively[2].
Synonyms	AM 103

Chemical Properties

Molecular Weight	631.76
Formula	C₃₆H₃₈N₃NaO₄S
Cas No.	1147872-22-7
Smiles	[Na+].COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C([O-])=O)c(SC(C)(C)C)c3cc(OCc4ccccn4)ccc23)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 180 mg/mL (284.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (7.91 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5829 mL	7.9144 mL	15.8288 mL	79.1440 mL
5 mM	0.3166 mL	1.5829 mL	3.1658 mL	15.8288 mL
10 mM	0.1583 mL	0.7914 mL	1.5829 mL	7.9144 mL
20 mM	0.0791 mL	0.3957 mL	0.7914 mL	3.9572 mL
50 mM	0.0317 mL	0.1583 mL	0.3166 mL	1.5829 mL
100 mM	0.0158 mL	0.0791 mL	0.1583 mL	0.7914 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc