Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impeding downstream signaling. Additionally, it facilitates the internalization and degradation of IGF-1R. Demonstrating extensive antitumor efficacy, it is relevant in cancer research, including lung and prostate cancers, malignancies, and leukemia [1].
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Description | Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impeding downstream signaling. Additionally, it facilitates the internalization and degradation of IGF-1R. Demonstrating extensive antitumor efficacy, it is relevant in cancer research, including lung and prostate cancers, malignancies, and leukemia [1]. |
In vitro | Cixutumumab (IMC-A12) demonstrates significant growth inhibition, achieving a minimum of 50% in CHLA-9, TC-71, and Rh41 cell lines upon exposure to concentrations ranging from 0.01 to 100 nM over a period of 96 hours [1]. |
In vivo | Cixutumumab (IMC-A12), administered intraperitoneally at a dose of 1 mg/rat twice weekly over a period of six weeks, demonstrates extensive antitumor efficacy, significantly suppressing the progression of solid tumors in the Pediatric Preclinical Testing Program's (PPTP's) in vivo models [1]. |
Synonyms | NSC742460, IMC-A12 |
Molecular Weight | N/A |
CAS No. | 947687-12-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Cixutumumab 947687-12-9 NSC742460 NSC 742460 IMC-A12 NSC-742460 inhibitor inhibit