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Anti-GPR109A Polyclonal Antibody (Synonyms: rHM74b, Puma-g, PUMAG, Puma g, Protein PUMA-G, Nicotinic acid r...)

Catalog No. TMAB-00787 Copy Product Info
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Anti-GPR109A Polyclonal Antibody is a Rabbit antibody targeting GPR109A. Anti-GPR109A Polyclonal Antibody can be used in WB.

Anti-GPR109A Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-00787
Synonyms rHM74b, Puma-g, PUMAG, Puma g, Protein PUMA-G, Nicotinic acid receptor 1, Nicotinic acid receptor, Niacr1, Niacin receptor 1, Interferon gamma inducible gene Puma g, HM74b, HM74a, HCAR2, G-protein coupled receptor HM74, G-protein coupled receptor 109A, G-protein coupled receptor 109, GPR109A, G protein coupled receptor Hm74b, G protein coupled receptor HM74a

Anti-GPR109A Polyclonal Antibody is a Rabbit antibody targeting GPR109A. Anti-GPR109A Polyclonal Antibody can be used in WB.

Anti-GPR109A Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2227-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5287-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-GPR109A Polyclonal Antibody is a Rabbit antibody targeting GPR109A. Anti-GPR109A Polyclonal Antibody can be used in WB.
SynonymsrHM74b, Puma-g, PUMAG, Puma g, Protein PUMA-G, Nicotinic acid receptor 1, Nicotinic acid receptor, Niacr1, Niacin receptor 1, Interferon gamma inducible gene Puma g, HM74b, HM74a, HCAR2, G-protein coupled receptor HM74, G-protein coupled receptor 109A, G-protein coupled receptor 109, GPR109A, G protein coupled receptor Hm74b, G protein coupled receptor HM74a
Ig Type
IgG
Reactivity
Human,Mouse (predicted:Rat,Cow,Rabbit)
Verified Activity
Sample:
Skin (Mouse) Lysate at 40 μg
Primary: Anti-GPR109R (TMAB-00787) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 40 kDa
Observed band size: 40 kDa
verifiedActivity
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue SpecificityExpression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundActs as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human GPR109A/HM74A
Antigen Species
Human
Gene Name
HCAR2
Gene ID
Protein Name
Hydroxycarboxylic acid receptor 2
Uniprot ID
Biology Area
Hydrolysis,p53 Pathway,Hydrolysis,Cancer,GPCR
Function
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Chemical Properties
Molecular WeightTheoretical: 40 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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