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HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated
(Synonyms: p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, erbB3-S, ErbB-3, erb-b2 receptor tyrosine kinase 3, EEBB3, c-erbB-3, c-erbB3) Copy Product InfoSynonyms: p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, erbB3-S, ErbB-3, erb-b2 receptor tyrosine kinase 3, EEBB3, c-erbB-3, c-erbB3
Catalog No. TMPY-04956 Copy Product Info
HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $95 | 7-10 days | 7-10 days | |
| 10 µg | $155 | 7-10 days | 7-10 days | |
| 20 µg | $256 | - | In Stock | |
| 50 µg | $397 | 7-10 days | 7-10 days | |
| 100 µg | $589 | 7-10 days | 7-10 days | |
| 200 µg | $1,000 | 7-10 days | 7-10 days | |
| 500 µg | $2,030 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:SDS-PAGE: 98.1%; SEC-HPLC: 96.2%
Appearance:Lyophilized powder
Color:White
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Recombinant Human NRG1 / Neuregulin 1 Protein (Fc Tag) at 2 μg/mL (100 μL/well) can bind Recombinant Human HER3 / ErbB3 Protein (His Tag), Biotinylated , the EC50 is 100-300 ng/mL. |
| Description | HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | P21860-1 |
| Construction | A DNA sequence encoding the extracellular domain (Met1-Thr643) of human ErbB3 (NP_001973.2) precursor was expressed with a C-terminal polyhistidine tag. The purified protein was biotinylated in vitro. Predicted N terminal: Ser 20 |
| Protein Purity | > 95% as determined by SDS-PAGE.  |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Synonyms | p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, erbB3-S, ErbB-3, erb-b2 receptor tyrosine kinase 3, EEBB3, c-erbB-3, c-erbB3 |
| Research Background | ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 70.2 kDa (predicted) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated chemical structure | HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated molecular weight
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