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Anti-XIAP Antibody (6P394)

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Catalog No. TMAB-14212

Anti-XIAP Antibody (6P394) is a Mouse antibody targeting XIAP. Anti-XIAP Antibody (6P394) can be used in WB.

Anti-XIAP Antibody (6P394)

Anti-XIAP Antibody (6P394)

😃Good
Catalog No. TMAB-14212
Anti-XIAP Antibody (6P394) is a Mouse antibody targeting XIAP. Anti-XIAP Antibody (6P394) can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2217-10 days7-10 days
100 μL$3717-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-XIAP Antibody (6P394) is a Mouse antibody targeting XIAP. Anti-XIAP Antibody (6P394) can be used in WB.
Ig Type
IgG1, k
Clone
6P394
Reactivity
Human
Application
Recommended Dose
WB: 1:500-5000
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCytoplasm.
Tissue SpecificityUbiquitous, except peripheral blood leukocytes.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
Antigen Details
Immunogen
Recombinant Protein: human XIAP
Antigen Species
Human
Gene Name
XIAP
Gene ID
Protein Name
E3 ubiquitin-protein ligase XIAP
Uniprot ID
Function
Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B.
Chemical Properties
Molecular WeightTheoretical: 55 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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