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Anti-XIAP Antibody (6P394)
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Catalog No. TMAB-14212
Anti-XIAP Antibody (6P394) is a Mouse antibody targeting XIAP. Anti-XIAP Antibody (6P394) can be used in WB.
Anti-XIAP Antibody (6P394)
Anti-XIAP Antibody (6P394)
Copy Product Info😃Good
Catalog No. TMAB-14212
Anti-XIAP Antibody (6P394) is a Mouse antibody targeting XIAP. Anti-XIAP Antibody (6P394) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-XIAP Antibody (6P394) is a Mouse antibody targeting XIAP. Anti-XIAP Antibody (6P394) can be used in WB. |
| Ig Type | IgG1, k |
| Clone | 6P394 |
| Reactivity | Human |
| Verified Activity | 1. Sample: Lane 1: Human MCF-7 cell lysates Lane 2: Human MOLT4 cell lysates Lane 3: Human HeLa cell lysates Lane 4: Human Raji cell lysates Lane 5: Human Jurkat cell lysates Lane 6: Human HepG2 cell lysates Lane 7: Human A549 cell lysates Primary: Anti-XIAP (TMAB-14212) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 55 kDa Observed band size: 55 kDa 2. 25 μg total protein per lane of various lysates (see on figure) probed with XIAP monoclonal antibody, unconjugated (TMAB-14212) at 1:5000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-5000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Ubiquitous, except peripheral blood leukocytes. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] |
| Immunogen | Recombinant Protein: human XIAP |
| Antigen Species | Human |
| Gene Name | XIAP |
| Gene ID | |
| Protein Name | E3 ubiquitin-protein ligase XIAP |
| Uniprot ID | |
| Function | Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. |
| Molecular Weight | Theoretical: 55 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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