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Anti-MYD88 Polyclonal Antibody
(Synonyms: Myeloid differentiation primary response protein MyD88, MYD88) Copy Product Info
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Synonyms: Myeloid differentiation primary response protein MyD88, MYD88
Catalog No. TMAB-01192 Copy Product Info
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Anti-MYD88 Polyclonal Antibody is a Rabbit antibody targeting MYD88. Anti-MYD88 Polyclonal Antibody can be used in FCM, IF, IHC-Fr, IHC-P, WB.
Anti-MYD88 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-MYD88 Polyclonal Antibody is a Rabbit antibody targeting MYD88. Anti-MYD88 Polyclonal Antibody can be used in FCM, IF, IHC-Fr, IHC-P, WB. |
| Synonyms | Myeloid differentiation primary response protein MyD88, MYD88 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | FCM=1 μg/Test; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Ubiquitous. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. |
| Immunogen | KLH conjugated synthetic peptide: mouse MyD88 |
| Antigen Species | Mouse |
| Gene Name | MYD88 |
| Gene ID | |
| Protein Name | Myeloid differentiation primary response protein MyD88 |
| Uniprot ID | |
| Biology Area | Inflammatory mediators,TLR Signaling,Cytoplasmic |
| Function | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. |
| Molecular Weight | Theoretical: 34 kDa. Actual: 32 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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