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Targapremir-210

Name: Targapremir-210
Brand: TargetMol
SKU: T16991
Price: 92 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16991Cas No. 1049722-30-6

Alias TGP-210

Targapremir-210 (TGP-210) is a selective and potent inhibitor of miRNA-210 (miRNA-210), which inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.

Targapremir-210

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Purity: 98%

Catalog No. T16991Alias TGP-210Cas No. 1049722-30-6

Targapremir-210 (TGP-210) is a selective and potent inhibitor of miRNA-210 (miRNA-210), which inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.

Pack Size	Price	Availability	Quantity
1 mg	$92	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98%

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COA LCMS

Product Introduction

Bioactivity

Description	Targapremir-210 (TGP-210) is a selective and potent inhibitor of miRNA-210 (miRNA-210), which inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.
Targets&IC50	miR-210:200 nM
In vitro	Targapremir-210 selectively reduces mature miR-210 levels in MDA-MB-231 cells under hypoxic conditions, achieving an IC50 of approximately 200 nM[1]. This compound specifically induces apoptosis in MDA-MB-231 cells exposed to hypoxia at 200 nM, while it does not trigger apoptosis in cells cultivated in normoxic environments[1].
In vivo	In vivo, a single intraperitoneal injection of Targapremir-210 (100 μL of 200 nM) impedes the proliferation of MDA-MB-231 triple-negative breast cancer (TNBC) cells. Targapremir-210 successfully reaches the tumor and sustains its presence throughout the entire 21-day period, leading to a reduction in tumor burden in a TNBC mouse model[1].
Synonyms	TGP-210

Chemical Properties

Molecular Weight	592.69
Formula	C₃₂H₃₆N₁₀O₂
Cas No.	1049722-30-6
Smiles	CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1ccc2nc([nH]c2c1)-c1cccc(OCCCC(=O)NCCCN=[N+]=[N-])c1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (168.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6872 mL	8.4361 mL	16.8722 mL	84.3611 mL
5 mM	0.3374 mL	1.6872 mL	3.3744 mL	16.8722 mL
10 mM	0.1687 mL	0.8436 mL	1.6872 mL	8.4361 mL
20 mM	0.0844 mL	0.4218 mL	0.8436 mL	4.2181 mL
50 mM	0.0337 mL	0.1687 mL	0.3374 mL	1.6872 mL
100 mM	0.0169 mL	0.0844 mL	0.1687 mL	0.8436 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc