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Decamethonium bromide

Name: Decamethonium bromide
Brand: TargetMol
SKU: T0818
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0818Cas No. 541-22-0

Alias Syncurine, Decacuran

Decamethonium bromide (Syncurine) is a neuromuscular blocker and nicotinic AChR partial agonist.

Decamethonium bromide

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Purity: 99.90%

Catalog No. T0818Alias Syncurine, DecacuranCas No. 541-22-0

Decamethonium bromide (Syncurine) is a neuromuscular blocker and nicotinic AChR partial agonist.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.90%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Decamethonium bromide (Syncurine) is a neuromuscular blocker and nicotinic AChR partial agonist.
In vivo	At the motor neuromuscular endplate, Decamethonium induces a depolarization that prevents the normal release of acetylcholine from presynaptic terminals from acting further, thereby preventing the nerve stimulus from affecting the muscle. During binding, Decamethonium actually activates (depolarizes) the motor endplate, but does not degrade itself, so the cell membrane remains depolarized and unresponsive to normal acetylcholine release. As a depolarizing muscle relaxant or neuromuscular blocker, Decamethonium is used in anesthesia to induce paralysis. It has a short duration of action similar to that of acetylcholine and acts as a partial agonist at nicotinic acetylcholine-like receptors.
Synonyms	Syncurine, Decacuran

Chemical Properties

Molecular Weight	418.29
Formula	C₁₆H₃₈Br₂N₂
Cas No.	541-22-0
Smiles	[Br-].[Br-].C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 77 mg/mL (184.08 mM), Sonication is recommended.

DMSO: 65 mg/mL (155.39 mM), Sonication is recommended.

Ethanol: 24 mg/mL (57.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3907 mL	11.9534 mL	23.9069 mL	119.5343 mL
5 mM	0.4781 mL	2.3907 mL	4.7814 mL	23.9069 mL
10 mM	0.2391 mL	1.1953 mL	2.3907 mL	11.9534 mL
20 mM	0.1195 mL	0.5977 mL	1.1953 mL	5.9767 mL
50 mM	0.0478 mL	0.2391 mL	0.4781 mL	2.3907 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
100 mM	0.0239 mL	0.1195 mL	0.2391 mL	1.1953 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc