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2-Methoxyestrone

Name: 2-Methoxyestrone
Brand: TargetMol
SKU: T13481
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13481Cas No. 362-08-3

2-Methoxyestrone is a methoxylated catechol estrogen and the principal metabolite of 2-hydroxyestrone [a nonuterotropic metabolite of estradiol].

2-Methoxyestrone

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Purity: 99.18%

Catalog No. T13481Cas No. 362-08-3

2-Methoxyestrone is a methoxylated catechol estrogen and the principal metabolite of 2-hydroxyestrone [a nonuterotropic metabolite of estradiol].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	-	In Stock
5 mg	$98	-	In Stock
10 mg	$163	-	In Stock
25 mg	$297	-	In Stock
50 mg	$439	-	In Stock
100 mg	$648	-	In Stock
200 mg	$926	-	In Stock
1 mL x 10 mM (in DMSO)	$108	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.18%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	2-Methoxyestrone is a methoxylated catechol estrogen and the principal metabolite of 2-hydroxyestrone [a nonuterotropic metabolite of estradiol].
In vivo	2-Methoxyestrone, given at noon of proestrus, significantly augments the magnitude of the preovulatory prolactin rise possibly by inhibiting the formation of endogenous 2-hydroxyestrogens in the brain[2].

Chemical Properties

Molecular Weight	300.39
Formula	C₁₉H₂₄O₃
Cas No.	362-08-3
Smiles	[H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3cc(OC)c(O)cc3CC[C@@]21[H]
Relative Density.	1.172g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 44 mg/mL (146.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3290 mL	16.6450 mL	33.2901 mL	166.4503 mL
5 mM	0.6658 mL	3.3290 mL	6.6580 mL	33.2901 mL
10 mM	0.3329 mL	1.6645 mL	3.3290 mL	16.6450 mL
20 mM	0.1665 mL	0.8323 mL	1.6645 mL	8.3225 mL
50 mM	0.0666 mL	0.3329 mL	0.6658 mL	3.3290 mL
100 mM	0.0333 mL	0.1665 mL	0.3329 mL	1.6645 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc