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Otaplimastat HCl
🥰Excellent
Catalog No. T24817LCas No. 1176758-02-3
Alias SP8203 HCl, SP 8203 HCl, Otaplimastat HCl (1176758-04-5 Free base)
Otaplimastat HCl is a matrix metalloproteinase (MMP) inhibitor that blocks NMDA receptor-mediated excitotoxicity competitively and exhibits antioxidant activity,In oxygen-glucose-deprived endothelial cells, otaplimastat suppressed the activity rather than protein expression of MMPs by restoring the level of tissue inhibitor of metalloproteinase (TIMP) suppressed in ischemia, and consequently reduced vascular permeation. serving as a tool for research into brain ischemic injury and neuroprotection.
Otaplimastat HCl
🥰Excellent
Purity: 100%
Catalog No. T24817LAlias SP8203 HCl, SP 8203 HCl, Otaplimastat HCl (1176758-04-5 Free base)Cas No. 1176758-02-3
Otaplimastat HCl is a matrix metalloproteinase (MMP) inhibitor that blocks NMDA receptor-mediated excitotoxicity competitively and exhibits antioxidant activity,In oxygen-glucose-deprived endothelial cells, otaplimastat suppressed the activity rather than protein expression of MMPs by restoring the level of tissue inhibitor of metalloproteinase (TIMP) suppressed in ischemia, and consequently reduced vascular permeation. serving as a tool for research into brain ischemic injury and neuroprotection.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $691 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock | |
| 100 mg | $1,960 | In Stock | |
| 200 mg | $2,680 | In Stock |
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Purity:100%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Otaplimastat HCl is a matrix metalloproteinase (MMP) inhibitor that blocks NMDA receptor-mediated excitotoxicity competitively and exhibits antioxidant activity,In oxygen-glucose-deprived endothelial cells, otaplimastat suppressed the activity rather than protein expression of MMPs by restoring the level of tissue inhibitor of metalloproteinase (TIMP) suppressed in ischemia, and consequently reduced vascular permeation. serving as a tool for research into brain ischemic injury and neuroprotection. |
| In vitro | Otaplimastat HCl (87.5-350 μM, 20 min) can protect neuronal cells through competitive action, preventing NMDA-induced cell death [1]. Otaplimastat HCl (350 μM) is capable of inhibiting calcium ion (Ca²⁺) influx triggered by NMDA receptor activation in primary cultured neurons [1]. When pretreated for 4 hours at concentrations of 2-200 μM, Otaplimastat HCl significantly suppresses hydrogen peroxide (H₂O₂)-induced cell death and reduces reactive oxygen species (ROS) generation [2]. |
| In vivo | In the middle cerebral artery occlusion (MCAO) model, intraperitoneal injection of Otaplimastat HCl (10-20 mg/kg) (administered once 30 minutes before occlusion and once 1 hour after reperfusion) prevented ischemic neuronal death [1]. Daily intraperitoneal injection of Otaplimastat HCl (5-10 mg/kg) for 10 consecutive days alleviated stroke-induced motor function impairment [2]. |
| Synonyms | SP8203 HCl, SP 8203 HCl, Otaplimastat HCl (1176758-04-5 Free base) |
| Molecular Weight | 571.07 |
| Formula | C28H35ClN6O5 |
| Cas No. | 1176758-02-3 |
| Smiles | Cl.O=C1NC=2C=CC=CC2C(=O)N1CCCNCCCCN(C(=O)C)CCCN3C(=O)NC=4C=CC=CC4C3=O |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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