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Otaplimastat HCl
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Catalog No. T24817LCas No. 1176758-02-3
Alias SP8203 HCl, SP 8203 HCl, Otaplimastat HCl (1176758-04-5 Free base)
Otaplimastat HCl is a matrix metalloproteinase (MMP) inhibitor that blocks NMDA receptor-mediated excitotoxicity competitively and exhibits antioxidant activity,In oxygen-glucose-deprived endothelial cells, otaplimastat suppressed the activity rather than protein expression of MMPs by restoring the level of tissue inhibitor of metalloproteinase (TIMP) suppressed in ischemia, and consequently reduced vascular permeation. serving as a tool for research into brain ischemic injury and neuroprotection.
Otaplimastat HCl
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Purity: 100%
Catalog No. T24817LAlias SP8203 HCl, SP 8203 HCl, Otaplimastat HCl (1176758-04-5 Free base)Cas No. 1176758-02-3
Otaplimastat HCl is a matrix metalloproteinase (MMP) inhibitor that blocks NMDA receptor-mediated excitotoxicity competitively and exhibits antioxidant activity,In oxygen-glucose-deprived endothelial cells, otaplimastat suppressed the activity rather than protein expression of MMPs by restoring the level of tissue inhibitor of metalloproteinase (TIMP) suppressed in ischemia, and consequently reduced vascular permeation. serving as a tool for research into brain ischemic injury and neuroprotection.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $691 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock | |
| 200 mg | $2,680 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:100%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Otaplimastat HCl is a matrix metalloproteinase (MMP) inhibitor that blocks NMDA receptor-mediated excitotoxicity competitively and exhibits antioxidant activity,In oxygen-glucose-deprived endothelial cells, otaplimastat suppressed the activity rather than protein expression of MMPs by restoring the level of tissue inhibitor of metalloproteinase (TIMP) suppressed in ischemia, and consequently reduced vascular permeation. serving as a tool for research into brain ischemic injury and neuroprotection. |
| In vitro | Otaplimastat HCl (87.5-350 μM, 20 min) can protect neuronal cells through competitive action, preventing NMDA-induced cell death [1]. Otaplimastat HCl (350 μM) is capable of inhibiting calcium ion (Ca²⁺) influx triggered by NMDA receptor activation in primary cultured neurons [1]. When pretreated for 4 hours at concentrations of 2-200 μM, Otaplimastat HCl significantly suppresses hydrogen peroxide (H₂O₂)-induced cell death and reduces reactive oxygen species (ROS) generation [2]. |
| In vivo | In the middle cerebral artery occlusion (MCAO) model, intraperitoneal injection of Otaplimastat HCl (10-20 mg/kg) (administered once 30 minutes before occlusion and once 1 hour after reperfusion) prevented ischemic neuronal death [1]. Daily intraperitoneal injection of Otaplimastat HCl (5-10 mg/kg) for 10 consecutive days alleviated stroke-induced motor function impairment [2]. |
| Synonyms | SP8203 HCl, SP 8203 HCl, Otaplimastat HCl (1176758-04-5 Free base) |
| Molecular Weight | 571.07 |
| Formula | C28H35ClN6O5 |
| Cas No. | 1176758-02-3 |
| Smiles | Cl.O=C1NC=2C=CC=CC2C(=O)N1CCCNCCCCN(C(=O)C)CCCN3C(=O)NC=4C=CC=CC4C3=O |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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