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Furosemide-d5

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Catalog No. TMIH-0248Cas No. 1189482-35-6

Furosemide-d5 is a deuterium marker for Furosemide and can be used in isotope tracer experiments.Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC), NKCC1, and NKCC2 cotransporter proteins and GABAA receptor antagonist and is used as diuretic reagent, congestive heart failure, hypertension and edema.

Furosemide-d5

Furosemide-d5

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Catalog No. TMIH-0248Cas No. 1189482-35-6
Furosemide-d5 is a deuterium marker for Furosemide and can be used in isotope tracer experiments.Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC), NKCC1, and NKCC2 cotransporter proteins and GABAA receptor antagonist and is used as diuretic reagent, congestive heart failure, hypertension and edema.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$379-In Stock
5 mg$1,0617-10 days7-10 days
10 mg$1,6987-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Furosemide-d5 is a deuterium marker for Furosemide and can be used in isotope tracer experiments.Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC), NKCC1, and NKCC2 cotransporter proteins and GABAA receptor antagonist and is used as diuretic reagent, congestive heart failure, hypertension and edema.
Chemical Properties
Molecular Weight335.78
FormulaC12H11ClN2O5S
Cas No.1189482-35-6
SmilesC(O)(=O)C1=C(NC(C2=C(C(=C(O2)[2H])[2H])[2H])([2H])[2H])C=C(Cl)C(S(N)(=O)=O)=C1
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (238.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9781 mL14.8907 mL29.7814 mL148.9070 mL
5 mM0.5956 mL2.9781 mL5.9563 mL29.7814 mL
10 mM0.2978 mL1.4891 mL2.9781 mL14.8907 mL
20 mM0.1489 mL0.7445 mL1.4891 mL7.4454 mL
50 mM0.0596 mL0.2978 mL0.5956 mL2.9781 mL
100 mM0.0298 mL0.1489 mL0.2978 mL1.4891 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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