Sortilin/SORT1 Protein, Human, Recombinant (His)

Name: Sortilin/SORT1 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-07180
Rating: 4.5 (1 reviews)

(Synonyms: NTR3, NT3, LDLCQ6, Gp95) Copy Product Info

Synonyms: NTR3, NT3, LDLCQ6, Gp95

Catalog No. TMPY-07180 Copy Product Info

Sortilin/SORT1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q99523-1.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$77	7-10 days	7-10 days
10 µg	$126	7-10 days	7-10 days
20 µg	$198	7-10 days	7-10 days
50 µg	$397	7-10 days	7-10 days
100 µg	$796	7-10 days	7-10 days
200 µg	$1,200	7-10 days	7-10 days
500 µg	$2,590	7-10 days	7-10 days
1 mg	$5,280	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Sortilin/SORT1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q99523-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q99523-1
Construction	A DNA sequence encoding the Human SORT1 (Q99523-1) (Ser78-Asn755) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity	≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Please refer to the lot-specific COA.
Synonyms	NTR3, NT3, LDLCQ6, Gp95
Research Background	SORT1 is the neuronal receptor for granulin, encoded by the progranulin gene (GRN), a major causal gene for inherited frontotemporal dementia (FTD). Even though sortilin binds and internalizes LDL by receptor-mediated endocytosis, mutations in the SORT1 gene are unlikely to cause autosomal dominant hypercholesterolemia and may only have a marginal effect on plasma LDL cholesterol levels. The SORT1 locus was originally identified by genome-wide association studies of low-density lipoprotein cholesterol (LDL-C) in adults.

Chemical Properties

Molecular Weight

77.20 kDa (predicted); 94.3 kDa (reducing contition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.