GBA Protein, Human, Recombinant (His & Myc & SUMO)

Name: GBA Protein, Human, Recombinant (His & Myc & SUMO)
Brand: TargetMol
SKU: TMPH-01623
Rating: 4.5 (1 reviews)

(Synonyms: Lysosomal glycosylceramidase, Lysosomal galactosylceramidase, Lysosomal cholesterol glycosyltransferase, Lysosomal acid glucosylceramidase, Lysosomal acid GCase, Imiglucerase, Glucosylceramidase beta 1, GLUC, GC, GBA1, GBA, D-glucosyl-N-acylsphingosine glucohydrolase, Cholesteryl-beta-glucosidase, Cholesterol glucosyltransferase (SGTase), Beta-glucosylceramidase 1, Beta-glucocerebrosidase (Beta-GC), Alglucerase, Acid beta-glucosidase) Copy Product Info

Synonyms: Lysosomal glycosylceramidase, Lysosomal galactosylceramidase, Lysosomal cholesterol glycosyltransferase, Lysosomal acid glucosylceramidase, Lysosomal acid GCase, Imiglucerase, Glucosylceramidase beta 1, GLUC, GC, GBA1, GBA, D-glucosyl-N-acylsphingosine glucohydrolase, Cholesteryl-beta-glucosidase, Cholesterol glucosyltransferase (SGTase), Beta-glucosylceramidase 1, Beta-glucocerebrosidase (Beta-GC), Alglucerase, Acid beta-glucosidase

Catalog No. TMPH-01623 Copy Product Info

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol.

GBA Protein, Human, Recombinant (His & Myc & SUMO)

Pack Size	Price	USA Stock	Global Stock
5 µg	$75	20 days	20 days
10 µg	$119	20 days	20 days
20 µg	$198	20 days	20 days
50 µg	$297	20 days	20 days
100 µg	$427	20 days	20 days
200 µg	$658	20 days	20 days
500 µg	$1,170	20 days	20 days
1 mg	$1,830	20 days	20 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol.
Species	Human
Expression System	E. coli
Tag	N-10xHis-SUMO, C-Myc
Accession Number	P04062
Amino Acid	ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
Construction	40-536 aa
Protein Purity	> 85% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Tris-based buffer, 50% glycerol
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	Lysosomal glycosylceramidase, Lysosomal galactosylceramidase, Lysosomal cholesterol glycosyltransferase, Lysosomal acid glucosylceramidase, Lysosomal acid GCase, Imiglucerase, Glucosylceramidase beta 1, GLUC, GC, GBA1, GBA, D-glucosyl-N-acylsphingosine glucohydrolase, Cholesteryl-beta-glucosidase, Cholesterol glucosyltransferase (SGTase), Beta-glucosylceramidase 1, Beta-glucocerebrosidase (Beta-GC), Alglucerase, Acid beta-glucosidase
Research Background	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol.

Chemical Properties

Molecular Weight

75.6 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

β-glucosylceramidase 1β-glucocerebrosidase (β-GC)β-GCβGCSGTaseGlucosylceramidase β 1Glucosylceramidase b 1GBA 1Cholesteryl-β-glucosidaseCholesteryl-b-glucosidaseb-glucosylceramidase 1b-glucocerebrosidase (b-GC)b-GCbGCBeta-GCBetaGCAcid β-glucosidaseAcid b-glucosidase

Related Tags: GBA Protein, Human, Recombinant (His & Myc & SUMO) chemical structure | GBA Protein, Human, Recombinant (His & Myc & SUMO) molecular weight