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1-Naphthyl PP1

Name: 1-Naphthyl PP1
Brand: TargetMol
SKU: T3935
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3935Cas No. 221243-82-9

Alias 1-NA-PP 1

1-Naphthyl PP1 (1-NA-PP 1) is a selective Src inhibitor, targeting v-Src and c-Fyn, c-Abl, CDK2, and CAMK II with IC50 values of 1.0, 0.6, 0.6, 18, and 22 μM, respectively.

1-Naphthyl PP1

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Purity: 99.85%

Catalog No. T3935Alias 1-NA-PP 1Cas No. 221243-82-9

1-Naphthyl PP1 (1-NA-PP 1) is a selective Src inhibitor, targeting v-Src and c-Fyn, c-Abl, CDK2, and CAMK II with IC50 values of 1.0, 0.6, 0.6, 18, and 22 μM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$208	In Stock	In Stock
50 mg	$338	In Stock	In Stock
100 mg	$546	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.85%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

1-Naphthyl PP1 AI Summary

1-Naphthyl PP1 exhibits potent bioactivity as an inhibitor of several kinases, including strong inhibition of v-Src mutant (IC50 = 1.5 nM), moderate inhibition of Fyn (IC50 = 600.0 nM), and weak inhibition of wild type v-Src (IC50 = 1000.0 nM). It also strongly inhibits the kinase mutant PKCepsilon type M486A (IC50 = 21.0 nM) but shows no significant inhibition towards other PKC isoforms. It exhibits mixed effects on a variety of kinases, with both inhibitory and stimulatory activities observed in different assays. The compound has a notable stabilizing effect on kinases such as AMPKA2, CAMK1D, and several others. Additionally, 1-Naphthyl PP1 shows bioactivity against parasitic enzymes, inhibiting Toxoplasma gondii CDPK1 with an IC50 of 2.13 nM and exhibiting antiparasitic activity against Toxoplasma gondii tachyzoites and Cryptosporidium parvum. Moreover, it displays antiviral activity against SARS-CoV-2 by inhibiting viral-induced cytotoxicity and SARS-CoV-2 3CL-Pro protease. Lastly, 1-Naphthyl PP1 inhibits human HDAC6 with varying inhibition percentages depending on the substrate used. These results suggest potential therapeutic applications of 1-Naphthyl PP1 in targeting kinases involved in various diseases and pathways, as well as its utility against specific parasitic and viral infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Naphthyl PP1 (1-NA-PP 1) is a selective Src inhibitor, targeting v-Src and c-Fyn, c-Abl, CDK2, and CAMK II with IC50 values of 1.0, 0.6, 0.6, 18, and 22 μM, respectively.
Targets&IC50	CaMK II:22 μM, c-Fyn:0.6 μM, PKD1:154.6 nM, v-Src:1.0 μM, PKD3:109.4 nM, c-ABL:0.6 μM, PKD2:133.4 nM, CDK2:18 μM
Synonyms	1-NA-PP 1

Chemical Properties

Molecular Weight	317.39
Formula	C₁₉H₁₉N₅
Cas No.	221243-82-9
Smiles	CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc12
Relative Density.	1.27g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (37.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1507 mL	15.7535 mL	31.5070 mL	157.5349 mL
5 mM	0.6301 mL	3.1507 mL	6.3014 mL	31.5070 mL
10 mM	0.3151 mL	1.5753 mL	3.1507 mL	15.7535 mL
20 mM	0.1575 mL	0.7877 mL	1.5753 mL	7.8767 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc