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Itasetron

Name: Itasetron
Brand: TargetMol
SKU: T24184
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24184Cas No. 123258-84-4

Alias UNII-00S0D0OEKR, U-98079A, U 98079A, DAU6215CL, DAU 6215CL

Itasetron (U 98079A) is a 5-hydroxytryptamine 3-receptor antagonist used to prevent age-related memory deficits in rats.Itasetron's antiemetic activity in animal models of cancer chemotherapy and radiation therapy may be useful in the study of amnesia.

Itasetron

🥰Excellent

Purity: 99.68%

Catalog No. T24184Alias UNII-00S0D0OEKR, U-98079A, U 98079A, DAU6215CL, DAU 6215CLCas No. 123258-84-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	In Stock	In Stock
5 mg	$348	In Stock	In Stock
10 mg	$475	In Stock	In Stock
25 mg	$667	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.68%

ee:99.86%

Appearance:Solid

Color:White

Resource Download

COA CSFC HNMR ORP HPLC

Product Introduction

Bioactivity

Description	Itasetron (U 98079A) is a 5-hydroxytryptamine 3-receptor antagonist used to prevent age-related memory deficits in rats.Itasetron's antiemetic activity in animal models of cancer chemotherapy and radiation therapy may be useful in the study of amnesia.
In vivo	Itasetron orally is rapidly absorbed (about 90 min), is highly bioavailable (greater than 90%), and has a long half-life (about 12 h). Itasetron (0.5, 1, 2, 4, and 8 mg; twice daily) in comparison with 8 mg b.i.d. ondansetron. Assessments were made in patients (n = 104) with histologically confirmed cancer (excluding head and neck tumors) and about to receive their first course of moderately emetogenic chemotherapy. Itasetron demonstrated comparable efficacy to ondansetron; no statistically significant between-group differences were observed in the primary (complete response rate) or secondary (nausea and delayed emesis) efficacy criteria. The tolerability of Itasetron was assessed as 'very good' or 'rather good' by 81% of patients and 89% of physicians. In conclusion, Itasetron is effective and well tolerated in patients receiving moderately emetogenic chemotherapy. Oral doses of 1 mg b.i.d. or above will be used in further clinical studies.[1]
Synonyms	UNII-00S0D0OEKR, U-98079A, U 98079A, DAU6215CL, DAU 6215CL

Chemical Properties

Molecular Weight	300.36
Formula	C₁₆H₂₀N₄O₂
Cas No.	123258-84-4
Smiles	C(N[C@H]1C[C@@]2(N(C)[C@](C1)(CC2)[H])[H])(=O)N3C=4C(NC3=O)=CC=CC4
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (149.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3293 mL	16.6467 mL	33.2934 mL	166.4669 mL
5 mM	0.6659 mL	3.3293 mL	6.6587 mL	33.2934 mL
10 mM	0.3329 mL	1.6647 mL	3.3293 mL	16.6467 mL
20 mM	0.1665 mL	0.8323 mL	1.6647 mL	8.3233 mL
50 mM	0.0666 mL	0.3329 mL	0.6659 mL	3.3293 mL
100 mM	0.0333 mL	0.1665 mL	0.3329 mL	1.6647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc