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Galanin Receptor Ligand M35 TFA
🥰Excellent
Catalog No. TP1704
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of the galanin receptor (Kd = 0.1 nM).
Galanin Receptor Ligand M35 TFA
🥰Excellent
Purity: 99.45%
Catalog No. TP1704
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of the galanin receptor (Kd = 0.1 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $113 | In Stock | |
| 5 mg | $336 | In Stock | |
| 10 mg | $473 | In Stock | |
| 25 mg | $738 | In Stock | |
| 50 mg | $996 | In Stock | |
| 100 mg | $1,330 | In Stock | |
| 200 mg | $1,780 | In Stock |
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Purity:99.45%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of the galanin receptor (Kd = 0.1 nM). |
| In vitro | Galanin Receptor Ligand M35 TFA exhibits dual effects on galanin-mediated inhibition of Forskolin-stimulated cyclic AMP production in Rin m 5F cells. At low concentrations (1 nM), co-applied with galanin (10 nM), it reverses galanin's inhibitory effect, while at higher concentrations (15 and 30 nM), it functions as a galanin receptor agonist, inhibiting cAMP production. These effects are not additive, reflecting its mixed agonist/antagonist properties due to its chimeric nature acting solely at galanin receptors[1]. |
| In vivo | Galanin Receptor Ligand M35 TFA (6 nM/10 μL; i.c.v.) enhances the performance of male Sprague-Dawley rats in the swim maze task by shortening escape latency, reducing failure rates in reaching the platform, and decreasing path length to the hidden platform[3]. |
| Molecular Weight | 2347.62 |
| Formula | C109H154N27F3O28 |
| Smiles | C[C@@H](O)[C@H](NC([C@@H](NC(CN)=O)CC1=CNC2=CC=CC=C21)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N3CCC[C@H]3C(N4CCC[C@H]4C(N5CCC[C@H]5C(NCC(N[C@H](C(N[C@H](C(N6CCC[C@H]6C(N[C@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)CC7=CC=CC=C7)=O)=O)CO)=O)CC8=CC=CC=C8)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC9=CC=C(O)C=C9)=O)=O)C)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O.OC(C(F)(F)F)=O |
| Relative Density. | no data available |
| Color | White |
| Appearance | solid |
| Sequence | {Gly}{Trp}{Thr}{Leu}{Asn}{Ser}{Ala}{Gly}{Tyr}{Leu}{Leu}{Gly}{Pro}{Pro}{Pro}{Gly}{Phe}{Ser}{Pro}{Phe}{Arg}-NH2 |
| Sequence Short | GWTLNSAGYLLGPPPGFSPFR-NH2 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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