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Galanin Receptor Ligand M35 TFA

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Catalog No. TP1704

Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of the galanin receptor (Kd = 0.1 nM).

Galanin Receptor Ligand M35 TFA
Other Forms of Galanin Receptor Ligand M35 TFA:
Galanin Receptor Ligand M35TP1662142846-71-7
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Galanin Receptor Ligand M35 TFA

🥰Excellent
Purity: 99.45%
Catalog No. TP1704
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of the galanin receptor (Kd = 0.1 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$113In StockIn Stock
5 mg$336In StockIn Stock
10 mg$473In StockIn Stock
25 mg$738In StockIn Stock
50 mg$996In StockIn Stock
100 mg$1,330In StockIn Stock
200 mg$1,780In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.45%
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Product Introduction

Bioactivity
Description
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of the galanin receptor (Kd = 0.1 nM).
In vitro
Galanin Receptor Ligand M35 TFA exhibits dual effects on galanin-mediated inhibition of Forskolin-stimulated cyclic AMP production in Rin m 5F cells. At low concentrations (1 nM), co-applied with galanin (10 nM), it reverses galanin's inhibitory effect, while at higher concentrations (15 and 30 nM), it functions as a galanin receptor agonist, inhibiting cAMP production. These effects are not additive, reflecting its mixed agonist/antagonist properties due to its chimeric nature acting solely at galanin receptors[1].
In vivo
Galanin Receptor Ligand M35 TFA (6 nM/10 μL; i.c.v.) enhances the performance of male Sprague-Dawley rats in the swim maze task by shortening escape latency, reducing failure rates in reaching the platform, and decreasing path length to the hidden platform[3].
Chemical Properties
Molecular Weight2347.62
FormulaC109H154N27F3O28
SmilesC[C@@H](O)[C@H](NC([C@@H](NC(CN)=O)CC1=CNC2=CC=CC=C21)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N3CCC[C@H]3C(N4CCC[C@H]4C(N5CCC[C@H]5C(NCC(N[C@H](C(N[C@H](C(N6CCC[C@H]6C(N[C@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)CC7=CC=CC=C7)=O)=O)CO)=O)CC8=CC=CC=C8)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC9=CC=C(O)C=C9)=O)=O)C)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O.OC(C(F)(F)F)=O
Relative Density.no data available
ColorWhite
Appearancesolid
Sequence{Gly}{Trp}{Thr}{Leu}{Asn}{Ser}{Ala}{Gly}{Tyr}{Leu}{Leu}{Gly}{Pro}{Pro}{Pro}{Gly}{Phe}{Ser}{Pro}{Phe}{Arg}-NH2
Sequence ShortGWTLNSAGYLLGPPPGFSPFR-NH2
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mM, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.4260 mL2.1298 mL4.2596 mL21.2982 mL
5 mM0.0852 mL0.4260 mL0.8519 mL4.2596 mL
10 mM0.0426 mL0.2130 mL0.4260 mL2.1298 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

NeuropeptideYReceptorNeuropeptide Y ReceptorGalanin Receptor Ligand M-35 TFAGalanin Receptor Ligand M35 TFAgalanin receptor
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