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Talazoparib tosylate

Name: Talazoparib tosylate
Brand: TargetMol
SKU: T16979
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16979Cas No. 1373431-65-2

Alias BMN673ts, BMN 673ts

Talazoparib tosylate (BMN 673ts) is an orally active and highly potent PARP1/2 inhibitor with antitumor activity for the study of specific breast cancers.

Talazoparib tosylate

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Purity: 99.79%

Catalog No. T16979Alias BMN673ts, BMN 673tsCas No. 1373431-65-2

Talazoparib tosylate (BMN 673ts) is an orally active and highly potent PARP1/2 inhibitor with antitumor activity for the study of specific breast cancers.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$137	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$328	-	In Stock
200 mg	$455	-	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Talazoparib tosylate (BMN 673ts) is an orally active and highly potent PARP1/2 inhibitor with antitumor activity for the study of specific breast cancers.
Targets&IC50	PARP1:1.20 nM (Ki), PARP2:0.85 nM (Ki)
In vitro	Talazoparib tosylate had similar inhibitory effects on PARP1 and PARP2 (Ki values of 1.20 nM and 0.85 nM, respectively). Talazoparib tosylate induced the formation of an intranuclear γ-H2AX focus at concentrations as low as 100 pM. Talazoparib tosylate had no effect on PARG activity at concentrations up to 1 μM. The dissociation constant for binding of Talazoparib tosylate to PARP1 was 0.29 nM. Talazoparib tosylate selectively targets tumor cells with defects in the BRCA1, BRCA2 or PTEN genes with 20- to 200-fold greater potency than existing PARP1/2 inhibitors. Talazoparib tosylate specifically targets tumor cells with defects in homologous recombination genes, and tumor models with defects in BRCA1 or BRCA2 defective tumor models are extremely sensitive to Talazoparib tosylate. [1]
In vivo	Talazoparib tosylate has high oral bioavailability, with absolute bioavailability exceeding 40% when administered orally in rats using carboxymethylcellulose as the vehicle. Talazoparib tosylate has significant antitumor effects when administered orally; Talazoparib tosylate exhibits high potency sensitivity in transplanted tumors with impaired DNA repair due to BRCA mutations or PTEN defects when administered at well-tolerated doses in mice. [1]
Synonyms	BMN673ts, BMN 673ts

Chemical Properties

Molecular Weight	552.55
Formula	C₂₆H₂₂F₂N₆O₄S
Cas No.	1373431-65-2
Smiles	S(=O)(=O)(O)C1=CC=C(C)C=C1.CN1C([C@H]2C=3C4=C(N[C@@H]2C5=CC=C(F)C=C5)C=C(F)C=C4C(=O)NN3)=NC=N1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 100 mg/mL (180.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8098 mL	9.0490 mL	18.0979 mL	90.4895 mL
5 mM	0.3620 mL	1.8098 mL	3.6196 mL	18.0979 mL
10 mM	0.1810 mL	0.9049 mL	1.8098 mL	9.0490 mL
20 mM	0.0905 mL	0.4524 mL	0.9049 mL	4.5245 mL
50 mM	0.0362 mL	0.1810 mL	0.3620 mL	1.8098 mL
100 mM	0.0181 mL	0.0905 mL	0.1810 mL	0.9049 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc