This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
TC-SP 14
Catalog No. T21916 CAS
1257093-40-5
TC-SP 14, also known as compound 14, is a highly active and potent S1P1 agonist with oral bioavailability. It exhibits an EC50 value of 0.042 μM, indicating its strong binding affinity to the S1P1 receptor. Notably, its interaction with the S1P3 receptor is minimal, as evidenced by an EC50 value of 3.47 μM. TC-SP 14 demonstrates significant pharmacological effects, including a marked reduction in blood lymphocyte counts and the attenuation of delayed type hypersensitivity response to antigen challenge [1].
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
TC-SP 14, also known as compound 14, is a highly active and potent S1P1 agonist with oral bioavailability. It exhibits an EC50 value of 0.042 μM, indicating its strong binding affinity to the S1P1 receptor. Notably, its interaction with the S1P3 receptor is minimal, as evidenced by an EC50 value of 3.47 μM. TC-SP 14 demonstrates significant pharmacological effects, including a marked reduction in blood lymphocyte counts and the attenuation of delayed type hypersensitivity response to antigen challenge [1].
In vitro
TC-SP 14 (compound 14) neither inhibits nor induces human cytochrome P450 enzymes. TC-SP 14 is nonmutagenic and does not significantly inhibit the hERG channel [1].
In vivo
TC-SP 14, administered orally at doses ranging from 0-3 mg/kg, induces a dose-dependent reduction in circulating lymphocytes 24 hours after administration, with maximal lymphopenia observed at 3.0 mg/kg, showing a 74% reduction compared to the control [1]. Daily oral administration of TC-SP 14 for 10 days at similar doses significantly mitigates ovalbumin (OVA)-induced ear swelling in a dose-dependent manner, with effective reduction starting from 0.3 mg/kg [1]. When administered either intravenously (IV) or orally (PO) at doses between 2-15 mg/kg, TC-SP 14 displays favorable pharmacokinetic properties, including low clearance rates, moderate steady-state volume of distribution, and moderate to long mean residence times, with acceptable oral bioavailability observed in Pharmacokinetic analysis involving female Sprague-Dawley rats and male Cynomolgus nonhuman primates [1]. These findings demonstrate TC-SP 14's potential as an immunomodulatory agent, with both acute and chronic administration showing beneficial effects on reducing lymphocyte counts and inflammatory responses effectively.
Molecular Weight
450.5
Formula
C25H20F2N2O2S
CAS No.
1257093-40-5
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.