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PROTAC K-Ras Degrader-5
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Catalog No. T201717Cas No. 3052745-16-8
Pan-KRAS degrader 4 (compound 69) is a cereblon-based PROTAC KRAS degrader exhibiting anticancer activity with a DC50 value of less than 100 nM.
PROTAC K-Ras Degrader-5
😃Good
Catalog No. T201717Cas No. 3052745-16-8
Pan-KRAS degrader 4 (compound 69) is a cereblon-based PROTAC KRAS degrader exhibiting anticancer activity with a DC50 value of less than 100 nM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pan-KRAS degrader 4 (compound 69) is a cereblon-based PROTAC KRAS degrader exhibiting anticancer activity with a DC50 value of less than 100 nM. |
| Targets&IC50 | KRas (G12D):<100nM(DC50) |
| Molecular Weight | 1025.17 |
| Formula | C57H63F3N10O5 |
| Cas No. | 3052745-16-8 |
| Smiles | O=C1C2=CC=C(C(F)=C2CN1C3C(=O)NC(=O)CC3)N4CCC(CN5CCC(CC5)CC6CCN(CCOC7=NC8=C(F)C(=NC=C8C(=N7)N9CC%10NC(C9)CC%10)C=%11C=C(O)C=C%12C=CC(F)=C(C#C)C%12%11)CC6)CC4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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