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Anti-Cytokeratin 2e Antibody (2U710)
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Catalog No. TMAB-04951
Anti-Cytokeratin 2e Antibody (2U710) is a Rabbit antibody targeting Cytokeratin 2e. Anti-Cytokeratin 2e Antibody (2U710) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA.
Anti-Cytokeratin 2e Antibody (2U710)
Anti-Cytokeratin 2e Antibody (2U710)
😃Good
Catalog No. TMAB-04951
Anti-Cytokeratin 2e Antibody (2U710) is a Rabbit antibody targeting Cytokeratin 2e. Anti-Cytokeratin 2e Antibody (2U710) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Cytokeratin 2e Antibody (2U710) is a Rabbit antibody targeting Cytokeratin 2e. Anti-Cytokeratin 2e Antibody (2U710) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA. |
| Ig Type | IgG |
| Clone | 2U710 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; ICC/IF: 1:50-200; IF: 1:50-200; ELISA: 1:5000-10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasmic. |
| Tissue Specificity | Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingival and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| Immunogen | Recombinant Protein: human Cytokeratin 2e protein, around 350-500aa |
| Antigen Species | Human |
| Gene Name | KRT2 |
| Gene ID | |
| Protein Name | Keratin, type II cytoskeletal 2 epidermal |
| Uniprot ID | |
| Function | Keratins are the major gene product of keratinocytes and form the intermediate filament cytoskeletal network in these cells. In cells of the upper spinous layer, KRT2E and KRT9 are expressed. Although the expression of KRT9 is limited to palmoplantar epidermis, KRT2E is expressed not only in this tissue but also in other regions, notably the epidermis covering the knee, thigh, and groin. It is not known whether these keratins simply replace their respective type I or type II counterpart in the preexisting KRT1/KRT10 network or dimerize with another, as yet undiscovered keratin partner. |
| Molecular Weight | Theoretical: 70 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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