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OATD-01

Name: OATD-01
Brand: TargetMol
SKU: T9592
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9592Cas No. 2088453-21-6

OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).

OATD-01

🥰Excellent

Purity: 99.59%

Catalog No. T9592Cas No. 2088453-21-6

OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
2 mg	$74	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$372	In Stock	In Stock
50 mg	$556	In Stock	In Stock
100 mg	$783	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.59%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).
Targets&IC50	Chitinase 1 (mouse):28 nM, AMCase (mouse):7.8 nM, CIT1 (human):23 nM, AMCase (human):9 nM
In vitro	The Ki values for hCHIT1,mCHIT1, hAMCase and mAMCase are 17.3 nM, 26.05 nM, 4.8 nM and 5.7 nM, respectively[1]. These Ki values reveals good correlation with earlier established IC50 data, which are 23 nM, 28 nM, 9 nM and 7.8 nM, respectively[1]. OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets[1].
In vivo	OATD-01 given orally once daily in a range of doses between 30 and 100 mg/kg showed significant antifibrotic efficacy in an animal model of bleomycin-induced pulmonary fibrosis[1].

Chemical Properties

Molecular Weight	390.91
Formula	C₁₉H₂₇ClN₆O
Cas No.	2088453-21-6
Smiles	C[C@H]1CN([C@@H](Cc2ccc(Cl)cc2)CO1)C1CCN(CC1)c1nc(N)n[nH]1
Relative Density.	1.297 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 85 mg/mL (217.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5581 mL	12.7907 mL	25.5813 mL	127.9067 mL
5 mM	0.5116 mL	2.5581 mL	5.1163 mL	25.5813 mL
10 mM	0.2558 mL	1.2791 mL	2.5581 mL	12.7907 mL
20 mM	0.1279 mL	0.6395 mL	1.2791 mL	6.3953 mL
50 mM	0.0512 mL	0.2558 mL	0.5116 mL	2.5581 mL
100 mM	0.0256 mL	0.1279 mL	0.2558 mL	1.2791 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc