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GS-9901

Name: GS-9901
Brand: TargetMol
SKU: T15420
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15420Cas No. 1640247-87-5

GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.

GS-9901

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Purity: 99.92%

Catalog No. T15420Cas No. 1640247-87-5

GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	In Stock	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$347	In Stock	In Stock
25 mg	$745	In Stock	In Stock
50 mg	$987	In Stock	In Stock
100 mg	$1,370	In Stock	In Stock
500 mg	$2,760	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA CSFC FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
Targets&IC50	PI3Kδ:1 nM
In vivo	In female Lewis rats with established collagen-induced arthritis (CIA), GS-9901 (0.3 mg/kg, 1 mg/kg, and 3 mg/kg; orally, twice daily for 7 days starting on the 10th day after the second collagen immunization) significantly reduced ankle swelling[1].

Chemical Properties

Molecular Weight	477.88
Formula	C₂₂H₁₇ClFN₉O
Cas No.	1640247-87-5
Smiles	[C@@H](NC=1C(C#N)=C(N)N=C(N)N1)(C=2N(C(=O)C=3C(N2)=C(F)C=CC3Cl)C=4C=CC=NC4)C5CC5
Relative Density.	1.71 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (251.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0926 mL	10.4629 mL	20.9258 mL	104.6288 mL
5 mM	0.4185 mL	2.0926 mL	4.1852 mL	20.9258 mL
10 mM	0.2093 mL	1.0463 mL	2.0926 mL	10.4629 mL
20 mM	0.1046 mL	0.5231 mL	1.0463 mL	5.2314 mL
50 mM	0.0419 mL	0.2093 mL	0.4185 mL	2.0926 mL
100 mM	0.0209 mL	0.1046 mL	0.2093 mL	1.0463 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc