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Mosnodenvir
🥰Excellent
Catalog No. T79141LCas No. 2043343-94-6
Alias JNJ-1802, JNJ 64281802
Mosnodenvir (JNJ-1802) is a pan-DENV inhibitor effective against all four serotypes of dengue viruses, with the advantage of being highly potent and orally bioavailable, and blocks viral replication by inhibiting the formation of the complex between NS3 and NS4B.
Mosnodenvir
🥰Excellent
Purity: 99.72%
Catalog No. T79141LAlias JNJ-1802, JNJ 64281802Cas No. 2043343-94-6
Mosnodenvir (JNJ-1802) is a pan-DENV inhibitor effective against all four serotypes of dengue viruses, with the advantage of being highly potent and orally bioavailable, and blocks viral replication by inhibiting the formation of the complex between NS3 and NS4B.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $154 | In Stock | |
| 5 mg | $325 | In Stock | |
| 10 mg | $513 | In Stock | |
| 25 mg | $872 | In Stock | |
| 50 mg | $1,310 | In Stock | |
| 100 mg | $1,960 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $416 | In Stock |
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Purity:99.72%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Mosnodenvir (JNJ-1802) is a pan-DENV inhibitor effective against all four serotypes of dengue viruses, with the advantage of being highly potent and orally bioavailable, and blocks viral replication by inhibiting the formation of the complex between NS3 and NS4B. |
| Targets&IC50 | SARS-CoV-2 XBB:0.43 μM (EC₅₀), SARS-CoV-2 BA.5:0.27 μM (EC₅₀) |
| In vitro | Mosnodenvir inhibited SARS-CoV-2 BA.5 and XBB in Vero E6 cells with EC₅₀ values of 0.27 μM and 0.43 μM, respectively, and showed broad-spectrum antiviral activity in other cell lines[1]. |
| In vivo | In hACE2 transgenic mice, Mosnodenvir (200 mg/kg, i.p., daily × 5 days) reduced lung viral titers by >99% and alleviated lung damage, with good oral bioavailability (>80%)[1]. |
| Alias | JNJ-1802, JNJ 64281802 |
| Molecular Weight | 582.98 |
| Formula | C26H22ClF3N2O6S |
| Cas No. | 2043343-94-6 |
| Smiles | C(C(NC1=CC(S(C)(=O)=O)=CC(OC)=C1)C2=C(OC)C=C(Cl)C=C2)(=O)C=3C=4C(NC3)=CC=C(OC(F)(F)F)C4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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