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Rosuvastatin Sodium (ZD4522 Sodium) is a selective and competitive HMG-CoA reductase (HMGCR) inhibitor (IC50=11 nM) with lipid-lowering and anti-atherosclerotic effects.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $30 | 7-10 days | 7-10 days | |
| 10 mg | $47 | 7-10 days | 7-10 days | |
| 25 mg | $67 | 7-10 days | 7-10 days | |
| 50 mg | $96 | 7-10 days | 7-10 days | |
| 100 mg | $138 | 7-10 days | 7-10 days | |
| 500 mg | $339 | 7-10 days | 7-10 days | |
| 1 mL x 10 mM (in DMSO) | $52 | 7-10 days | 7-10 days |
| Description | Rosuvastatin Sodium (ZD4522 Sodium) is a selective and competitive HMG-CoA reductase (HMGCR) inhibitor (IC50=11 nM) with lipid-lowering and anti-atherosclerotic effects. |
| Targets&IC50 | HMG-CoA:11 nM, ERG (human):195 nM |
| In vivo | Rosuvastatin Sodium (10 mg/kg, intraperitoneal injection) prolonged the QTc interval from 201±1 ms to 210±2 ms in conscious unrestrained guinea pigs [2]. Rosuvastatin Sodium (20 mg/kg/day, administered continuously for 2 weeks) significantly reduced very low-density lipoprotein (VLDL) levels in streptozotocin-induced diabetes mellitus rats [4]. |
| Synonyms | ZD4522 Sodium, ZD 4522 Sodium, X-Plended Sodium, Crestor Sodium |
| Molecular Weight | 503.52 |
| Formula | C22H27FN3NaO6S |
| Cas No. | 147098-18-8 |
| Smiles | C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C=1C(=NC(N(S(C)(=O)=O)C)=NC1C(C)C)C2=CC=C(F)C=C2.[Na] |
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200 mg/mL (397.2 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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