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Rosuvastatin Sodium

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Catalog No. T63430Cas No. 147098-18-8
Alias ZD4522 Sodium, ZD 4522 Sodium, X-Plended Sodium, Crestor Sodium

Rosuvastatin Sodium (ZD4522 Sodium) is a selective and competitive HMG-CoA reductase (HMGCR) inhibitor (IC50=11 nM) with lipid-lowering and anti-atherosclerotic effects.

Rosuvastatin Sodium
Other Forms of Rosuvastatin Sodium:

Rosuvastatin Sodium

😃Good
Catalog No. T63430Alias ZD4522 Sodium, ZD 4522 Sodium, X-Plended Sodium, Crestor SodiumCas No. 147098-18-8
Rosuvastatin Sodium (ZD4522 Sodium) is a selective and competitive HMG-CoA reductase (HMGCR) inhibitor (IC50=11 nM) with lipid-lowering and anti-atherosclerotic effects.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$307-10 days7-10 days
10 mg$477-10 days7-10 days
25 mg$677-10 days7-10 days
50 mg$967-10 days7-10 days
100 mg$1387-10 days7-10 days
500 mg$3397-10 days7-10 days
1 mL x 10 mM (in DMSO)$527-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Rosuvastatin Sodium (ZD4522 Sodium) is a selective and competitive HMG-CoA reductase (HMGCR) inhibitor (IC50=11 nM) with lipid-lowering and anti-atherosclerotic effects.
Targets&IC50
HMG-CoA:11 nM, ERG (human):195 nM
In vivo
Rosuvastatin Sodium (10 mg/kg, intraperitoneal injection) prolonged the QTc interval from 201±1 ms to 210±2 ms in conscious unrestrained guinea pigs [2].
Rosuvastatin Sodium (20 mg/kg/day, administered continuously for 2 weeks) significantly reduced very low-density lipoprotein (VLDL) levels in streptozotocin-induced diabetes mellitus rats [4].
SynonymsZD4522 Sodium, ZD 4522 Sodium, X-Plended Sodium, Crestor Sodium
Chemical Properties
Molecular Weight503.52
FormulaC22H27FN3NaO6S
Cas No.147098-18-8
SmilesC(=C/[C@H](C[C@H](CC(O)=O)O)O)\C=1C(=NC(N(S(C)(=O)=O)C)=NC1C(C)C)C2=CC=C(F)C=C2.[Na]
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (397.2 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9860 mL9.9301 mL19.8602 mL99.3009 mL
5 mM0.3972 mL1.9860 mL3.9720 mL19.8602 mL
10 mM0.1986 mL0.9930 mL1.9860 mL9.9301 mL
20 mM0.0993 mL0.4965 mL0.9930 mL4.9650 mL
50 mM0.0397 mL0.1986 mL0.3972 mL1.9860 mL
100 mM0.0199 mL0.0993 mL0.1986 mL0.9930 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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