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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment of respiratory disorders and Camlipixant has a strong cough suppressant effect.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 239.00 | |
10 mg | In stock | $ 389.00 | |
25 mg | In stock | $ 738.00 | |
50 mg | In stock | $ 1,150.00 | |
100 mg | In stock | $ 1,550.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 239.00 |
Description | Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment of respiratory disorders and Camlipixant has a strong cough suppressant effect. |
Targets&IC50 | P2X3 (human):25 nM, P2X3 (rat):92 nM, P2X2/3 (rat):1820 nM, P2X3 (guinea pig):126 nM, P2X2/3 (guinea pig):3450 nM |
In vitro | Camlipixant (BLU-5937 ; 500 nM) blocks ATP-mediated sensitization of dorsal root ganglion (DRG) neurons.[1] |
In vivo |
Camlipixant (BLU-5937 ; 3-30 mg/kg ; oral) reduces histamine and ATP-induced cough sensitization in guinea pigs.[1] Camlipixant (BLU-5937 ; 10-20 mg/kg ; i.p.) did not alter taste perception compared to control animals.[1] Camlipixant (BLU-5937) exhibits excellent drug-like properties, including good oral bioavailability, low predicted clearance in humans, no blood-brain barrier permeability, and high safety.[1] |
Synonyms | BLU-5937 |
Molecular Weight | 458.46 |
Formula | C23H24F2N4O4 |
CAS No. | 1621164-74-6 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (49.08 mM)
You can also refer to dose conversion for different animals. More
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Camlipixant 1621164-74-6 Membrane transporter/Ion channel Neuroscience P2X Receptor BLU5937 BLU 5937 BLU-5937 inhibitor inhibit