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Camlipixant

Name: Camlipixant
Brand: TargetMol
SKU: T67885
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67885Cas No. 1621164-74-6

Alias BLU-5937

Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment of respiratory disorders and Camlipixant has a strong cough suppressant effect.

Camlipixant

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Purity: 99.37%

Catalog No. T67885Alias BLU-5937Cas No. 1621164-74-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
5 mg	$239	In Stock	In Stock
10 mg	$389	In Stock	In Stock
25 mg	$738	In Stock	In Stock
50 mg	$1,150	-	In Stock
100 mg	$1,550	-	In Stock
1 mL x 10 mM (in DMSO)	$239	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.37%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment of respiratory disorders and Camlipixant has a strong cough suppressant effect.
Targets&IC50	P2X3 (human):25 nM, P2X3 (rat):92 nM, P2X2/3 (guinea pig):3450 nM, P2X2/3 (rat):1820 nM, P2X3 (guinea pig):126 nM
In vitro	Camlipixant (BLU-5937 ; 500 nM) blocks ATP-mediated sensitization of dorsal root ganglion (DRG) neurons.[1]
In vivo	Camlipixant (BLU-5937 ; 3-30 mg/kg ; oral) reduces histamine and ATP-induced cough sensitization in guinea pigs.[1] Camlipixant (BLU-5937 ; 10-20 mg/kg ; i.p.) did not alter taste perception compared to control animals.[1] Camlipixant (BLU-5937) exhibits excellent drug-like properties, including good oral bioavailability, low predicted clearance in humans, no blood-brain barrier permeability, and high safety.[1]
Synonyms	BLU-5937

Chemical Properties

Molecular Weight	458.46
Formula	C₂₃H₂₄F₂N₄O₄
Cas No.	1621164-74-6
Smiles	C(C1=C(N=C2N1C=CC(C)=C2)C3=C(F)C=C(C(NC)=O)C=C3F)[C@H]4CN(C(OC)=O)CCO4
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (49.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1812 mL	10.9061 mL	21.8122 mL	109.0608 mL
5 mM	0.4362 mL	2.1812 mL	4.3624 mL	21.8122 mL
10 mM	0.2181 mL	1.0906 mL	2.1812 mL	10.9061 mL
20 mM	0.1091 mL	0.5453 mL	1.0906 mL	5.4530 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc