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SRI-29329

Name: SRI-29329
Brand: TargetMol
SKU: T8801
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8801Cas No. 2086809-58-5

SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).

SRI-29329

🥰Excellent

Purity: 99.18%

Catalog No. T8801Cas No. 2086809-58-5

SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).

Pack Size	Price	Availability
1 mg	$84	In Stock
5 mg	$198	In Stock
10 mg	$323	In Stock
25 mg	$547	In Stock
50 mg	$788	In Stock
100 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$226	In Stock

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Purity:99.18%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).
Targets&IC50	CLK2:16 nM , CLK4:86 nM, CLK1:78 nM

Chemical Properties

Molecular Weight	399.92
Formula	C₂₀H₂₆ClN₇
Cas No.	2086809-58-5
Smiles	CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32.5 mg/mL (81.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5005 mL	12.5025 mL	25.0050 mL	125.0250 mL
5 mM	0.5001 mL	2.5005 mL	5.0010 mL	25.0050 mL
10 mM	0.2501 mL	1.2503 mL	2.5005 mL	12.5025 mL
20 mM	0.1250 mL	0.6251 mL	1.2503 mL	6.2513 mL
50 mM	0.0500 mL	0.2501 mL	0.5001 mL	2.5005 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc