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Anti-Phospho-TRIM25 (Ser100) Polyclonal Antibody
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Catalog No. TMAB-11388
Anti-Phospho-TRIM25 (Ser100) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TRIM25 (Ser100). Anti-Phospho-TRIM25 (Ser100) Polyclonal Antibody can be used in WB.
Anti-Phospho-TRIM25 (Ser100) Polyclonal Antibody
Anti-Phospho-TRIM25 (Ser100) Polyclonal Antibody
😃Good
Catalog No. TMAB-11388
Anti-Phospho-TRIM25 (Ser100) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TRIM25 (Ser100). Anti-Phospho-TRIM25 (Ser100) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-TRIM25 (Ser100) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TRIM25 (Ser100). Anti-Phospho-TRIM25 (Ser100) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. |
| Tissue Specificity | Ubiquitous. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc binding domains, a RING, a B box type 1 and a B box type 2, and a coiled coil region. The protein localizes to the cytoplasm. The presence of potential DNA binding and dimerization transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human TRIM25 around the phosphorylation site of Ser100 |
| Antigen Species | Human |
| Gene Name | TRIM25 |
| Gene ID | |
| Protein Name | E3 ubiquitin/ISG15 ligase TRIM25 |
| Uniprot ID | |
| Function | Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. |
| Molecular Weight | Theoretical: 71 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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