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NKP-1339

Name: NKP-1339
Brand: TargetMol
SKU: TQ0016
Rating: 4.5 (1 reviews)

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Catalog No. TQ0016Cas No. 197723-00-5

Alias KP-1339, IT-139

NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.

NKP-1339

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Catalog No. TQ0016Alias KP-1339, IT-139Cas No. 197723-00-5

NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$198	5 days	5 days
5 mg	$347	5 days	5 days
25 mg	$1,140	6-8 weeks	6-8 weeks
50 mg	$1,490	6-8 weeks	6-8 weeks
100 mg	$1,990	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$383	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.
In vitro	NKP-1339 can strongly bind to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu.
Synonyms	KP-1339, IT-139

Chemical Properties

Molecular Weight	502.14
Formula	C₁₄H₁₂Cl₄N₄NaRu
Cas No.	197723-00-5
Smiles	[Na+].[Cl-][Ru+3]([Cl-])([Cl-])([Cl-])([N]1=CC=2C=CC=CC2N1)[N]3=CC=4C=CC=CC4N3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (109.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9915 mL	9.9574 mL	19.9148 mL	99.5738 mL
5 mM	0.3983 mL	1.9915 mL	3.9830 mL	19.9148 mL
10 mM	0.1991 mL	0.9957 mL	1.9915 mL	9.9574 mL
20 mM	0.0996 mL	0.4979 mL	0.9957 mL	4.9787 mL
50 mM	0.0398 mL	0.1991 mL	0.3983 mL	1.9915 mL
100 mM	0.0199 mL	0.0996 mL	0.1991 mL	0.9957 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc