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AKR1C3-IN-9

Name: AKR1C3-IN-9
Brand: TargetMol
SKU: T67846
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67846

AKR1C3-IN-9, a selective Aldo-keto Reductase 1C3 (AKR1C3) inhibitor (IC50 = 8.92 nM), can significantly reverse Doxorubicin (DOX) resistance in a resistant breast cancer cell line.

AKR1C3-IN-9

🥰Excellent

Purity: 99.98%

Catalog No. T67846

AKR1C3-IN-9, a selective Aldo-keto Reductase 1C3 (AKR1C3) inhibitor (IC50 = 8.92 nM), can significantly reverse Doxorubicin (DOX) resistance in a resistant breast cancer cell line.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	-	In Stock
25 mg	$83	-	In Stock
50 mg	$138	-	In Stock
100 mg	$226	-	In Stock
1 mL x 10 mM (in DMSO)	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AKR1C3-IN-9, a selective Aldo-keto Reductase 1C3 (AKR1C3) inhibitor (IC50 = 8.92 nM), can significantly reverse Doxorubicin (DOX) resistance in a resistant breast cancer cell line.
Targets&IC50	AKR1C3:8.92 nM
In vitro	AKR1C3-IN-9 (compound 24) (10-100 μM; 72 h and 96 h) shows a weak antiproliferative effect on three breast cancer cell lines (MDA-MB-231, MCF-7) with an inhibition range of up to 100 μM. AKR1C3-IN-9 (10 μM, 25 μM, 50 μM; 72 hours) in conjunction with 10-50 μM DOX synergistically inhibits the proliferation of MCF-7 cells. AKR1C3-IN-9 (10 μM; 8 d) with 50 μM DOX synergistically inhibits the proliferation and clonal survival of MCF-7/DOX cell lines, reinstating sensitivity to DOX [1].

Chemical Properties

Molecular Weight	352.38
Formula	C₂₀H₂₀N₂O₄
Smiles	CC1=C(C(=NO1)C)COC2=CC=CC=C2C(=O)NC3=CC=CC=C3OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (141.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8378 mL	14.1892 mL	28.3785 mL	141.8923 mL
5 mM	0.5676 mL	2.8378 mL	5.6757 mL	28.3785 mL
10 mM	0.2838 mL	1.4189 mL	2.8378 mL	14.1892 mL
20 mM	0.1419 mL	0.7095 mL	1.4189 mL	7.0946 mL
50 mM	0.0568 mL	0.2838 mL	0.5676 mL	2.8378 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	1.4189 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc