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(S,R,S)-AHPC-C3-NH2

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Catalog No. T18664Cas No. 2361119-88-0
Alias VH032-C3-NH2

(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized conjugate comprising an E3 ligase ligand-linker and a VH032-based VHL ligand, commonly used in PROTAC technology. This compound is essential in synthesizing various PROTACs, such as UNC6852, a bivalent chemical degrader that specifically targets EED [1].

(S,R,S)-AHPC-C3-NH2
Other Forms of (S,R,S)-AHPC-C3-NH2:

(S,R,S)-AHPC-C3-NH2

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Catalog No. T18664Alias VH032-C3-NH2Cas No. 2361119-88-0
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized conjugate comprising an E3 ligase ligand-linker and a VH032-based VHL ligand, commonly used in PROTAC technology. This compound is essential in synthesizing various PROTACs, such as UNC6852, a bivalent chemical degrader that specifically targets EED [1].
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Product Introduction

Bioactivity
Description
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized conjugate comprising an E3 ligase ligand-linker and a VH032-based VHL ligand, commonly used in PROTAC technology. This compound is essential in synthesizing various PROTACs, such as UNC6852, a bivalent chemical degrader that specifically targets EED [1].
In vitro
PROTACs comprise two distinct ligands joined by a linker: one targets an E3 ubiquitin ligase and the other binds to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. [PROTACs]
SynonymsVH032-C3-NH2
Chemical Properties
Molecular Weight515.67
FormulaC26H37N5O4S
Cas No.2361119-88-0
SmilesC([C@@H](NC(CCCN)=O)[C@@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Relative Density.1.242 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

VHLAHPC-C3-NH2(S,R,S)-AHPC-C-3-NH2(S,R,S)AHPCC3NH2(S,R,S) AHPC C3 NH2
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