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TH7127

Name: TH7127
Brand: TargetMol
SKU: T85342
Price: 620 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T85342

Alias TH7-127, TH7 127

TH7127 is a selective inhibitor of the sterile alpha motif and histidine-aspartate domain-containing protein-1 (SAMHD1), inhibits hydrolysis of ara-CTP and Cl-F-ara-ATP, and inhibits the enzymatic activity of SAMHD1 on dGTP, Cl-F-ara-ATP, and ara-CTP.

TH7127

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Purity: 99.82%

Catalog No. T85342Alias TH7-127, TH7 127

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$620	-	In Stock
5 mg	$1,370	-	In Stock
10 mg	$2,055	-	In Stock
25 mg	$3,500	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Oil

Color:Yellow to Black

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TH7127 is a selective inhibitor of the sterile alpha motif and histidine-aspartate domain-containing protein-1 (SAMHD1), inhibits hydrolysis of ara-CTP and Cl-F-ara-ATP, and inhibits the enzymatic activity of SAMHD1 on dGTP, Cl-F-ara-ATP, and ara-CTP.
Synonyms	TH7-127, TH7 127

Chemical Properties

Molecular Weight	345.4
Formula	C₂₀H₁₉N₅O
Smiles	COc1ccccc1-c1cn2ccnc2c(NCCc2ccccn2)n1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 100 mg/mL (289.52 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8952 mL	14.4760 mL	28.9519 mL	144.7597 mL
5 mM	0.5790 mL	2.8952 mL	5.7904 mL	28.9519 mL
10 mM	0.2895 mL	1.4476 mL	2.8952 mL	14.4760 mL
20 mM	0.1448 mL	0.7238 mL	1.4476 mL	7.2380 mL
50 mM	0.0579 mL	0.2895 mL	0.5790 mL	2.8952 mL
100 mM	0.0290 mL	0.1448 mL	0.2895 mL	1.4476 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc